Evidence map›Paper›PMID 27295011›Full record

ArticleJAMA pediatrics2016

Association Between Maternal Prepregnancy Body Mass Index and Plasma Folate Concentrations With Child Metabolic Health.

Guoying Wang, Frank B Hu, Kamila B Mistry, Cuilin Zhang, Fazheng Ren, Yong Huo, David Paige, Tami Bartell, Xiumei Hong, Deanna Caruso and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

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  16. Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Guoying WangDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Frank B HuDepartments of Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts3Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Kamila B MistryDivision of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins, University School of Medicine, Baltimore, Maryland.
Cuilin ZhangDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland5Division of Intramural Population Health Research, Eunice Kennedy Shriver N.
Fazheng RenBeijing Advanced Innovation Center for Food Nutrition and Human Health, China Agriculture University, Beijing, China.
Yong HuoDepartment of Cardiology, Peking University First Hospital, Beijing, China.
David PaigeDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Tami BartellStanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Xiumei HongDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Deanna CarusoDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Zhicheng JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Zhu ChenDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Yuelong JiDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Colleen PearsonDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.
Hongkai JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Barry ZuckermanDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.
Tina L ChengDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland4Division of General Pediatrics and Adolescent Medicine, Department of Pedia.
Xiaobin WangDepartment of Population, Family, and Reproductive Health, Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland4Division of General Pediatrics and Adolescent Medicine, Department of Pedia.
Johns Hopkins University · USBoston University · USJohns Hopkins Medicine · USBrigham and Women's Hospital · USLurie Children's Hospital · USPeking University First Hospital · CN

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth CohortR01HD086013 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y, WANG, XIAOBIN · 2016 to 2020
$3.3M
Post Genome-Wide Association Study of Food AllergyU01AI090727 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2014
$2.3M
Molecular Epidemiology of Preterm BirthR21ES011666 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2002 to 2004
$562k
Establishing Precursors of Food Allergy in NewbornsR21AI079872 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2008 to 2009
$447k
Epigenome-wide Association Study of Preterm BirthR21HD066471 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$354k
NIAID NIH HHS R21 AI079872NIAID NIH HHS U01 AI090727NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD086013NICHD NIH HHS R21 HD066471NIEHS NIH HHS R21 ES011666
6 · The paper itself

Abstract

importancePrevious reports have linked maternal prepregnancy obesity with low folate concentrations and child overweight or obesity (OWO) in separate studies. To our knowledge, the role of maternal folate concentrations, alone or in combination with maternal OWO, in child metabolic health has not been examined in a prospective birth cohort.

objectiveTo test the hypotheses that maternal folate concentrations can significantly affect child metabolic health and that sufficient maternal folate concentrations can mitigate prepregnancy obesity-induced child metabolic risk. DESIGN, SETTING, AND

participantsThis prospective birth cohort study was conducted at the Boston Medical Center, Boston, Massachusetts. It included 1517 mother-child dyads recruited at birth from 1998 to 2012 and followed up prospectively up to 9 years from 2003 to 2014. MAIN OUTCOMES AND MEASURES: Child body mass index z score calculated according to US reference data, OWO defined as a body mass index in the 85th percentile or greater for age and sex, and metabolic biomarkers (leptin, insulin, and adiponectin).

resultsThe mean (SD) age was 28.6 (6.5) years for mothers and 6.2 (2.4) years for the children. An L-shaped association between maternal folate concentrations and child OWO was observed: the risk for OWO was higher among those in the lowest quartile (Q1) as compared with those in Q2 through Q4, with an odds ratio of 1.45 (95% CI, 1.13-1.87). The highest risk for child OWO was found among children of obese mothers with low folate concentrations (odds ratio, 3.05; 95% CI, 1.91-4.86) compared with children of normal-weight mothers with folate concentrations in Q2 through Q4 after accounting for multiple covariables. Among children of obese mothers, their risk for OWO was associated with a 43% reduction (odds ratio, 0.57; 95% CI, 0.34-0.95) if their mothers had folate concentrations in Q2 through Q4 compared with Q1. Similar patterns were observed for child metabolic biomarkers. CONCLUSIONS AND RELEVANCE: In this urban low-income prospective birth cohort, we demonstrated an L-shaped association between maternal plasma folate concentrations and child OWO and the benefit of sufficient folate concentrations, especially among obese mothers. The threshold concentration identified in this study exceeded the clinical definition of folate deficiency, which was primarily based on the hematological effect of folate. Our findings underscore the need to establish optimal rather than minimal folate concentrations for preventing adverse metabolic outcomes in the offspring.

Indexed as

AdultBiomarkersBody Mass IndexBostonChildChild, PreschoolFemaleFolic AcidHumansInsulinLeptinMaleMetabolic DiseasesObesityOverweightPediatric ObesityBiomarkersFolic AcidInsulinLeptinVitamin B 12

Identifiers

PMID27295011
PMCPMC5147730
OpenAlexW2436994948

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.