ArticleMolecules (Basel, Switzerland)2016
Evaluation of the Antibacterial Effects and Mechanism of Action of Protocatechualdehyde against Ralstonia solanacearum.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Metabolic activation of pyruvate cycle by protocatechualdehyde triggers oxidative killing of ampicillin-resistantMicrobiology spectrum · 2026Article
- Medicinal Plants Facilitate the Recovery of Diabetic Foot Ulcer by Regulating Macrophages: Latest Evidence and Insights.Current diabetes reviews · 2026Review
- Research Progress on the Application of Novel Wound Healing Dressings in Different Stages of Wound Healing.Pharmaceutics · 2025Review
- Pathogenic Ralstonia solanacearum in Agriculture: A Review of Prevention and Control Strategies Based on Natural Products.Current microbiology · 2025Review
- Engineered biomimetic nanovesicles-laden multifunctional hydrogel enhances targeted therapy of diabetic wound.Materials today. Bio · 2024Article
- Antibacterial Activity and Mechanism of Three Root Exudates from Mulberry Seedlings againstPlants (Basel, Switzerland) · 2024Article
- Antibacterial and antibiofilm activities of protocatechualdehyde and its synergy with ampicillin against methicillin-resistantFrontiers in microbiology · 2024Article
- Procatechuic acid and protocatechuic aldehyde increase survival ofFrontiers in pharmacology · 2024Article
- UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among fourFrontiers in nutrition · 2024Article
- Multifunctional ADM hydrogel containing endothelial cell-exosomes for diabetic wound healing.Materials today. Bio · 2023Article
- Transcriptome Analysis of Protocatechualdehyde againstFoods (Basel, Switzerland) · 2023Article
- All-Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Induced defense strategies of plants againstFrontiers in microbiology · 2023Review
- Review
- Membrane damage mechanism of protocatechualdehyde against Micrococcus luteus and its effect on pork quality characteristics.Scientific reports · 2022Article
- Antibiofilm effect and mechanism of protocatechuic aldehyde againstFrontiers in microbiology · 2022Article
- Effects of pH and Temperature on Water under Pressurized Conditions in the Extraction of Nutraceuticals from Chaga (Antioxidants (Basel, Switzerland) · 2021Article
- Preliminary Studies on the Antibacterial Mechanism of a New Plant-Derived Compound, 7-Methoxycoumarin, AgainstFrontiers in microbiology · 2021Article
- Synergistic Activity of Capsaicin and Colistin Against Colistin-ResistantFrontiers in pharmacology · 2021Article
- Caffeic Acid in Tobacco Root Exudate Defends Tobacco Plants From Infection byFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protocatechualdehyde (PCA) is an important plant-derived natural product that has been associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging and an anti-inflammatory agent. However, fewer reports concerning its antibacterial effects on plant-pathogenic bacteria exist. Therefore, in this study, protocatechualdehyde was evaluated for its antibacterial activity against plant pathogens along with the mechanism of its antibacterial action. PCA at 40 μg/mL was highly active against R. solanacearum and significantly inhibited its growth. The minimum bactericidal concentration and minimum inhibitory concentration values for PCA were 40 μg/mL and 20 μg/mL, respectively. Further investigation of the mechanism of action of PCA via transmission electron microscopy and biological assays indicated that the destruction of the cell structure, the shapes and the inhibition of biofilm formation were important. In addition, the application of PCA effectively reduced the incidence of bacterial wilt on tobacco under greenhouse conditions, and the control efficiency was as high as 92.01% at nine days after inoculation. Taken together, these findings suggest that PCA exhibits strong antibacterial activity against R. solanacearum and has the potential to be applied as an effective antibacterial agent for controlling bacterial wilt caused by R. solanacearum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.