Trial reportPloS one2016
A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00998413 (Secondary Prevention of Asthma in Overweight/Obese Children by a Combined Dietary-behavioural-physical Activity Intervention), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Secondary Prevention of Asthma in Overweight/Obese Children by a Combined Dietary-behavioural-physical Activity Intervention
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Weight Loss for Children and Adults with Obesity and Asthma. A Systematic Review of Randomized Controlled Trials.Annals of the American Thoracic Society · 2019Pooled it
- School-based self-management interventions for asthma in children and adolescents: a mixed methods systematic review.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of metabolic syndrome on pulmonary infection in pediatric bronchial asthma: a narrative review.Frontiers in pediatrics · 2026Review
- Mechanisms of Innate Immune Modulation by High-Fat Diet: Implications for Obesity and Asthma.Current allergy and asthma reports · 2025Review
- Non-Communicable Diseases in Children: Systems-Based Approaches to Incorporating Nutrition into Medical Care.Children (Basel, Switzerland) · 2025Article
- Association of relative fat mass with asthma: inflammatory markers as potential mediators.Lipids in health and disease · 2025Article
- Management of the pediatric patient with asthma and obesity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Beyond the Metabolic Syndrome: Non-Obvious Complications of Obesity in Children.Children (Basel, Switzerland) · 2023Review
- Breast feeding, obesity, and asthma association: clinical and molecular views.Clinical and molecular allergy : CMA · 2023Review
- Evidence Base Update on Behavioral Treatments for Overweight and Obesity in Children and Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2023Review
- Does BMI Modify the Association between Vitamin D and Pulmonary Function in Children of the Mild Asthma Phenotype?International journal of environmental research and public health · 2022Article
- Leptin and Asthma: What Are the Interactive Correlations?Biomolecules · 2022Review
- The Impact of Dietary Intervention in Obese Children on Asthma Prevention and Control.Nutrients · 2022Review
- Obesity Is Associated with Sustained Symptomatology and Unique Inflammatory Features in Children with Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.The journal of allergy and clinical immunology. In practice · 2022Article
- An Overview of the Obese-Asthma Phenotype in Children.International journal of environmental research and public health · 2022Review
- Pediatric Obesity-Related Asthma: The Role of Nutrition and Nutrients in Prevention and Treatment.Nutrients · 2021Review
- Pilot study of a brief provider and EMR-based intervention for overweight teens with asthma.Pilot and feasibility studies · 2021Article
- The impact of obesity on immune function in pediatric asthma.Current opinion in allergy and clinical immunology · 2021Review
- Childhood Obesity and Respiratory Diseases: Which Link?Children (Basel, Switzerland) · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.
objectiveTo determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.
methodsAn 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.
resultsAfter 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC% predicted improved over time by 10.1 ± 8.7% in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4% in the control group (p<0.05). CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.
trial registrationClinicalTrials.gov NCT00998413.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.