Evidence map›Paper›PMID 27294813›Full record

ArticleJournal of the American Geriatrics Society2016

Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology.

Jason L Sanders, Jatinder Singh, Ryan L Minster, Jeremy D Walston, Amy M Matteini, Kaare Christensen, Richard Mayeux, Ingrid B Borecki, Thomas Perls, Anne B Newman and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study.International journal of environmental research and public health · 2023
    Observational
  4. Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  5. Quantifying and Classifying Physical Resilience Among Older Adults: The Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  6. Testing the Geroscience Hypothesis: Early Days.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jason L SandersDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jatinder SinghDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Ryan L MinsterDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jeremy D WalstonDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland.
Amy M MatteiniDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland.
Kaare ChristensenDepartment of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
Richard MayeuxDepartment of Neurology, Columbia University, New York, New York.
Ingrid B BoreckiDivision of Statistical Genetics, Washington University in St. Louis, St. Louis, Missouri.
Thomas PerlsDepartment of Medicine, Boston University, Boston, Massachusetts.
Anne B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Long Life Family Study Research Group

Funding

Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
The Long Life Family StudyU01AG023755 · NIA · BOSTON MEDICAL CENTER · PI PERLS, THOMAS T · 2004 to 2018
$13.2M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI Tyson Brown · 2009 to 2026
$12.2M
Multicenter Study on Exceptional Survival in Families: The Long Life Family StudyU01AG023744 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B., ZMUDA, JOSEPH M. · 2004 to 2018
$12.0M
Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field CenterU01AG023712 · NIA · DUKE UNIVERSITY · PI CHRISTENSEN, KAARE · 2004 to 2018
$10.4M
NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG034424NIA NIH HHS U01 AG023712NIA NIH HHS U01 AG023744NIA NIH HHS U01 AG023746NIA NIH HHS U01 AG023749NIA NIH HHS U01 AG023755
6 · The paper itself

Abstract

objectivesTo investigate the association between mortality and heritability of a rescaled Fried frailty index, the Scale of Aging Vigor in Epidemiology (SAVE), to determine its value for genetic analyses.

designLongitudinal, community-based cohort study.

settingThe Long Life Family Study (LLFS) in the United States and Denmark.

participantsLong-lived individuals (N = 4,875, including 4,075 genetically related individuals) and their families (N = 551). MEASUREMENTS: The SAVE was administered to 3,599 participants and included weight change, weakness (grip strength), fatigue (questionnaire), physical activity (days walked in prior 2 weeks), and slowness (gait speed); each component was scored 0, 1, or 2 using approximate tertiles, and summed (range 0 (vigorous) to 10 (frail)). Heritability was determined using a variance component-based family analysis using a polygenic model. Association with mortality in the proband generation (N = 1,421) was calculated using Cox proportional hazards mixed-effect models.

resultsHeritability of the SAVE was 0.23 (P < .001) overall (n = 3,599), 0.31 (P < .001) in probands (n = 1,479), and 0.26 (P < .001) in offspring (n = 2,120). In adjusted models, higher SAVE scores were associated with higher mortality (score 5-6: hazard ratio (HR) = 2.83, 95% confidence interval (CI) = 1.46-5.51; score 7-10: HR = 3.40, 95% CI = 1.72-6.71) than lower scores (0-2).

conclusionThe SAVE was associated with mortality and was moderately heritable in the LLFS, suggesting a genetic component to age-related vigor and frailty and supporting its use for further genetic analyses.

Indexed as

GenotypeAged, 80 and overBody WeightCohort StudiesCross-Cultural ComparisonDenmarkDisability EvaluationExerciseFemaleFrail ElderlyGaitHand StrengthHealth StatusHumansLongevityLongitudinal Studiesepidemiologyfrailtygeneticslongevityphenotype

Identifiers

PMID27294813
PMCPMC4988884

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.