Evidence map›Paper›PMID 27294752›Full record

ArticleJournal of racial and ethnic health disparities2016

US Mortality: Influence of Race, Geography and Cardiovascular Risk Among Participants in the Population-Based REGARDS Cohort.

Nita A Limdi, Virginia J Howard, John Higginbotham, Jason Parton, Monika M Safford, George Howard

Abstract read
In one paragraph

Article in Journal of racial and ethnic health disparities, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. DECODING STROKE DISPARITIES: ZIP CODES, COLOR CODES, AND EPIGENETIC CODES.Transactions of the American Clinical and Climatological Association · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Cardiovascular Diseases in African Americans: Fostering Community Partnerships to Stem the Tide.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018
    Review
  18. Factors Associated with Atraumatic Posterosuperior Rotator Cuff Tears.The Journal of bone and joint surgery. American volume · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nita A LimdiDepartment of Neurology, University of Alabama at Birmingham, 1235 Jefferson Tower, 625 19th Street South, Birmingham, AL, 35294-0021, USA. nlimdi@uab.edu.
Virginia J HowardDepartments of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
John HigginbothamDepartment of Community and Rural Medicine, University of Alabama, Tuscaloosa, AL, USA.
Jason PartonDepartment of Information Systems, Statistics, and Management Science University of Alabama, Tuscaloosa, AL, USA.
Monika M SaffordDepartments of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
George HowardDepartments of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
Predictors of hemorrhage among patients on direct acting oral anticoagulantsR01HL092173 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2008 to 2023
$10.4M
Patient Oriented Research in Personalized Antithrombotic TherapyK24HL133373 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2016 to 2025
$1.2M
Building Capacity for Cardiometabolic Outcomes ResearchK24HL111154 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAFFORD, MONIKA M · 2012 to 2015
$556k
NHLBI NIH HHS K24 HL111154NHLBI NIH HHS K24 HL133373NHLBI NIH HHS R01 HL080477NHLBI NIH HHS R01 HL092173NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

objectivesWe evaluated whether differences in cardiovascular risk factors, as assessed by the Framingham risk scores for stroke and cardiovascular disease (FSRS and FCRS), contributed to disparities in all-cause mortality across race and regional strata of USA.

designRace-region-specific FSRS and FCRS scores were computed for 30,086 REGARDS participants who were recruited between January 2003 and October 2007. They were divided across six regions of the "Eight Americas" and then compared after adjusting for race and sex. Kaplan-Meier curves and hazard ratios for all-cause mortality were estimated between regions, first adjusted for age and sex, and then for the risk scores.

resultsAfter adjustment for age, sex, FCRS, and FSRS, there was no difference in mortality among Middle-America Whites versus Low-Income White. However, mortality was lower among Middle-America Blacks (-23 %; p = 0.06) and High-Risk Urban Blacks (-24 %; p = 0.01) compared to Southern Low-Income Rural Blacks. Compared to Middle-American Whites, mortality was higher among Middle-America Blacks (+39 %; p < 0.001), High-Risk Urban Blacks (+35 %; p < 0.001) and Southern Low-Income Rural Blacks (+85 %; p < 0.001).

conclusionAccounting for cardiovascular risk unmasked a greater disparity in mortality between Blacks and Whites and among Southern Rural Blacks compared to Middle-America Blacks and High-Risk Urban Blacks.

Indexed as

Racial GroupsAdultAgedBlack or African AmericanBlack PeopleCardiovascular DiseasesCohort StudiesGeographyHumansMiddle AgedRisk FactorsRural PopulationUnited StatesWhite PeopleCardiovascular riskGeographyMortalityRace

Identifiers

PMID27294752
PMCPMC4911314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.