ArticleBosnian journal of basic medical sciences2016
Differential expression of androgen, estrogen, and progesterone receptors in benign prostatic hyperplasia.
Article in Bosnian journal of basic medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Identification of programmed cell death associated key genes in benign prostatic hyperplasia and prostate cancer development by integrated bioinformatics analysis and machine learning.Translational andrology and urology · 2025Article
- Protective effect of the hydroethanolic extract of camelthorn (Alhagi maurorum) on benign prostatic hyperplasia induced by testosterone in rats.BMC complementary medicine and therapies · 2025Article
- Network pharmacology and experimental validation to explore the pharmacological mechanism of saw palmetto and its core ingredients in benign prostatic hyperplasia treatment.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- C11-hydroxy and C11-oxo CInternational journal of molecular sciences · 2023Article
- Genome-wide association study identifies a role for the progesterone receptor in benign prostatic hyperplasia risk.Prostate cancer and prostatic diseases · 2021Article
- Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes.Nature communications · 2020Article
- Oral exposure of sulpiride promotes the proliferation of Brown-Norway rat prostates.Experimental and therapeutic medicine · 2020Article
- Estrogen regulates the proliferation and inflammatory expression of primary stromal cell in benign prostatic hyperplasia.Translational andrology and urology · 2020Article
- Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils.International journal of experimental pathology · 2019Article
- Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia.Research and reports in urology · 2019Review
- Progesterone Receptors in Prostate Cancer: Progesterone receptor B is the isoform associated with disease progression.Scientific reports · 2018Article
- N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Anti-proliferative activities of finasteride in benign prostate epithelial cells require stromal fibroblasts and c-Jun gene.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to identify the differential expression levels of androgen receptor (AR), estrogen receptors (ERα, ERβ), and progesterone receptor (PGR) between normal prostate and benign prostatic hyperplasia (BPH). The combination of immunohistochemistry, quantitative real-time reverse transcription polymerase chain reaction, and Western blotting assay was used to identify the distribution and differential expression of these receptors at the immunoactive biomarker, transcriptional, and protein levels between 5 normal human prostate tissues and 40 BPH tissues. The results were then validated in a rat model of BPH induced by testosterone propionate and estradiol benzoate. In both human and rat prostate tissues, AR was localized mainly to epithelial and stromal cell nuclei; ERα was distributed mainly to stromal cells, but not exclusively; ERβ was interspersed in the basal layer of epithelium, but sporadically in epithelial and stromal cells; PGR was expressed abundantly in cytoplasm of epithelial and stromal cells. There were decreased expression of ERα and increased expression of PGR, but no difference in the expression of ERβ in the BPH compared to the normal prostate of both human and rat. Increased expression of AR in the BPH compared to the normal prostate of human was observed, however, the expression of AR in the rat prostate tissue was decreased. This study identified the activation of AR and PGR and repression of ERα in BPH, which indicate a promoting role of AR and PGR and an inhibitory role of ERα in the pathogenesis of BPH.
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