ArticlePloS one2016
Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- How should we be using biomarkers in trials of disease modification in Parkinson's disease?Brain : a journal of neurology · 2023Article
- Neuroimaging Techniques in Differentiating Parkinson's Disease from Drug-Induced Parkinsonism: A Comprehensive Review.Clinics and practice · 2023Review
- Striatal serotonin transporter gain-of-function in L-DOPA-treated, hemi-parkinsonian rats.Brain research · 2023Article
- Clinical Aspects of the Differential Diagnosis of Parkinson's Disease and Parkinsonism.Journal of clinical neurology (Seoul, Korea) · 2022Review
- Dopamine Transporter Imaging, Current Status of a Potential Biomarker: A Comprehensive Review.International journal of molecular sciences · 2021Review
- Recognition and Management of Antipsychotic-Induced Parkinsonism in Older Adults: A Narrative Review.Medicines (Basel, Switzerland) · 2021Review
- Clinical features of drug-induced Parkinsonism.Neurology international · 2018Article
- Presynaptic dopamine depletion determines the timing of levodopa-induced dyskinesia onset in Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2018Article
- Early perfusion and dopamine transporter imaging usingAmerican journal of nuclear medicine and molecular imaging · 2018Review
- Microstructural white matter alterations in patients with drug induced parkinsonism.Human brain mapping · 2017Article
- Incidence and time trends of drug-induced parkinsonism: A 30-year population-based study.Movement disorders : official journal of the Movement Disorder Society · 2017Article
- Acute Cervical Dystonia Induced by Clebopride.Case reports in neurological medicine · 2017Article
- Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism.Journal of movement disorders · 2017Article
- Mirtazapine-associated movement disorders: A literature review.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish drug-induced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semi-quantitative analysis of 18F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The 18F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.
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Registered trials
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