Evidence map›Paper›PMID 27294327›Full record

ArticleThe Journal of clinical endocrinology and metabolism2016

Triglyceride Levels and Fracture Risk in Midlife Women: Study of Women's Health Across the Nation (SWAN).

Po-Yin Chang, Ellen B Gold, Jane A Cauley, Wesley O Johnson, Carrie Karvonen-Gutierrez, Elizabeth A Jackson, Kristine M Ruppert, Jennifer S Lee

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  5. Review
  6. Article
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  11. Major osteoporosis fracture prediction in type 2 diabetes: a derivation and comparison study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Bone Health During the Menopause Transition and Beyond.Obstetrics and gynecology clinics of North America · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Po-Yin ChangDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Ellen B GoldDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Jane A CauleyDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Wesley O JohnsonDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Carrie Karvonen-GutierrezDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Elizabeth A JacksonDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Kristine M RuppertDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
Jennifer S LeeDivision of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California; Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, California; Department of Epidemiology (J.A.C., K.M.R.), University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania; Department of Statistics (W.O.J.), University of California, Irvine, Irvine, California; 5Department of Epidemiology (C.K.-G.), University of Michigan School of Public Health, Ann Arbor, Michigan; Division of Cardiovascular Medicine (E.A.J.), Department of Medicine, University of Michigan Health Systems, Ann Arbor, Michigan; Medical Services (J.S.L.), Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
University of Pittsburgh · USMichigan Medicine · USStanford University · USUniversity of California, Davis · USUniversity of California, Irvine · USUniversity of Michigan–Ann Arbor · USVA Palo Alto Health Care System · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
Hip Strength Across the Menopausal TransitionR01AG026463 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2007 to 2018
$3.9M
Metabolic Syndrome as Women Undergo Menopausal Transition: A Multi-Ethnic StudyR21AG040568 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEE, JENNIFER S · 2011 to 2013
$392k
NCRR NIH HHS UL1 RR024131NIA NIH HHS R01 AG026463NIA NIH HHS R21 AG040568NIA NIH HHS U01 AG012495NIA NIH HHS U01 AG012505NIA NIH HHS U01 AG012531NIA NIH HHS U01 AG012535NIA NIH HHS U01 AG012539NIA NIH HHS U01 AG012546NIA NIH HHS U01 AG012553NIA NIH HHS U01 AG012554NINR NIH HHS U01 NR004061
6 · The paper itself

Abstract

contextUnfavorable lipid levels contribute to cardiovascular disease and may also harm bone health.

objectiveOur objective was to investigate relationships between fasting plasma lipid levels and incident fracture in midlife women undergoing the menopausal transition. DESIGN AND

settingThis was a 13-year prospective, longitudinal study of multiethnic women in five US communities, with near-annual assessments.

participantsAt baseline, 2062 premenopausal or early perimenopausal women who had no history of fracture were included. EXPOSURES: Fasting plasma total cholesterol, triglycerides (TG), low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol at baseline and follow-up visits 1 and 3-7. MAIN OUTCOME MEASURE(S): Incident nontraumatic fractures 1) 2 or more years after baseline, in relation to a single baseline level of lipids; and 2) 2-5 years later, in relation to time-varying lipid levels. Cox proportional hazards modelings estimated hazard ratios and 95% confidence interval (CI).

resultsAmong the lipids, TG levels changed the most, with median levels increased by 16% during follow-up. An increase of 50 mg/dl in baseline TG level was associated with a 1.1-fold increased hazards of fracture (adjusted hazard ratio, 1.11; 95% CI, 1.04-1.18). Women with baseline TG higher than 300 mg/dl had an adjusted 2.5-fold greater hazards for fractures (95% CI, 1.13-5.44) than women with baseline TG lower than 150 mg/dl. Time-varying analyses showed a comparable TG level-fracture risk relationship. Associations between total cholesterol, low-density lipoprotein cholesterol, or high-density lipoprotein cholesterol levels and fractures were not observed.

conclusionsMidlife women with high fasting plasma TG had an increased risk of incident nontraumatic fracture. Secondary Abstract: Midlife women with fasting plasma triglyceride (TG) of at least 300 mg/dl had 2.5-fold greater hazards of fracture in 2 years later and onward, compared to those with TG below 150 mg/dl, in a multiethnic cohort. Time-varying analyses revealed comparable results.

Indexed as

Women's HealthAdultBiomarkersFemaleFollow-Up StudiesHumansHypertriglyceridemiaLongitudinal StudiesMenopauseMiddle AgedOsteoporotic FracturesPrognosisProspective StudiesRisk FactorsTriglyceridesBiomarkersTriglycerides

Identifiers

PMID27294327
PMCPMC5010577
OpenAlexW2434887627

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.