ArticleInternational journal of reproductive biomedicine2016
Effects of Portulaca oleracea ethanolic extract on reproductive system of aging female mice.
Article in International journal of reproductive biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
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- Immunohistochemical, histopathological, and biochemical studies of the NF-ҡB P65 marker in rat ovaries experimentally intoxicated by cadmium and the protective effect of the purslane plant extract.Environmental science and pollution research international · 2021Article
- Lipophilic and hydrophilic leaf extracts ofJournal of traditional and complementary medicine · 2021Article
- Reproductive toxicity potentials of methanolic extract ofInternational journal of reproductive biomedicine · 2021Article
- Molting method alternative and detection of estrogen receptors by immunohistochemical methods on molted layers.Tropical animal health and production · 2021Article
- The effects of myricitrin and vitamin E against reproductive changes induced by D-galactose as an aging model in female mice: An experimental study.International journal of reproductive biomedicine · 2019Article
- A Pharmacological Review onJournal of pharmacopuncture · 2019Review
- A proteomic approach reveals the differential protein expression inJournal of ginseng research · 2018Article
- Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway.International journal of molecular medicine · 2018Article
- Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice.Oxidative medicine and cellular longevity · 2016Article
- The effect ofIndian journal of pharmacologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging contains morphological and functional deterioration in biological systems. D-galactose (D-gal) generates free radicals and accelerates aging. Portulaca oleracea (Purslane) may have protective effect against oxidative stress.
objectivePurslane ethanolic extract effects were evaluated on antioxidant indices and sex hormone in D-gal aging female mice. MATERIALS AND
methods48 female NMRI mice (25-35 gr) were randomly divided into, 6 groups: 1- control (normal saline for 45 days), 2- Purslane (200 mg/kg for last 3 weeks), 3-D-gal (500 mg/kg for 45 days), 4-D-gal+Purslane, 5- Aging, 6-Aging+Purslane. Sex hormones, antioxidants and malondialdehyde (MDA) level of ovary and uterus were measured. Histological assessment was also done.
resultsIn D-gal treated and aging animals, LH and FSH levels were significantly increased (p<0.001) while estrogen and progesterone levels were significantly reduced (p<0.001) in comparison with control group. MDA contents were significantly increased in ovaries and uterus of D-gal and aging groups (p<0.01). Superoxide dismutase (SOD) (p<0.001) and catalase (p<0.01) activities were significantly decreased in both aging and D-gal treated animals. Ovarian follicles were degenerated and atrophy on uterine wall and endometrial glands was observed in D-gal and aging groups. Alteration in hormone levels, MDA contents and antioxidant activity were significantly reversed by Purslane (p<0.05). Purslane could also improve histological changes such as atrophy of endometrium.
conclusionThese findings indicate that Purslane can attenuate aging alternations induced by D-gal and aging in female reproductive system.
Indexed as
Identifiers
27294220PMC4899767W2336817397What OpenQuestion holds
Registered trials
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