ArticleInternational journal of reproductive biomedicine2016
Relationship between sperm protamine deficiency and apoptosis in couples with unexplained repeated spontaneous abortions.
Article in International journal of reproductive biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Association between early embryo morphokinetics plus transcript levels of sperm apoptotic genes and clinical outcomes in IMSI and ICSI cycles of male factor patients.Journal of assisted reproduction and genetics · 2020Trial
- Is there a correlation between male partner's previous tuberculosis and recurrent pregnancy loss (RPL)? - a single-center retrospective analysis.Open medicine (Warsaw, Poland) · 2026Article
- Moringa oleifera Lam. As a Herbal Antioxidant-Enriched Semen Extender in Cryopreservation: A Critical Review of Its Protective Potential.Veterinary medicine and science · 2026Review
- Peripheral Blood Expression of MMPs and DNA Methylation-Related Genes in Women with Recurrent Spontaneous Abortion: A Case-Control Study.F1000Research · 2025Article
- Male factor testing in recurrent pregnancy loss cases: A narrative review.International journal of reproductive biomedicine · 2022Review
- Evaluating Vitamin D and foxp3 mRNA levels in women with recurrent spontaneous abortion.JBRA assisted reproduction · 2022Article
- Impact of Vitamin C on Gene Expression Profile of Inflammatory and Anti-Inflammatory Cytokines in the Male Partners of Couples with Recurrent Pregnancy Loss.International journal of inflammation · 2022Article
- Effects of different doses of tamoxifen on the sperm parameters and chromatin quality in mice: An experimental model.International journal of reproductive biomedicine · 2019Article
- The effect of human sperm chromatin maturity on ICSI outcomes.Human cell · 2018Article
- Epigenetic Disruption as a Molecular Signature in Idiopathic Nonobstructive Azoospermia.American journal of men's healthArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEtiology of more than half of Recurrent Spontaneous Abortion. The etiology of more than 50 percent of Recurrent Spontaneous Abortions (RSA) cases has been remained unexplained. It is supposed that RSA may have "paternal effect" due to supply 50% of embryonic genomic content by male gamete.
objectiveThe aim of present study was to evaluate the role of sperm apoptosis and protamine deficiency at same time in RSA cases. MATERIALS AND
methodsForty fertile (control) and 40 unfertile men with RSA (case) were enrolled in this case-control study. Semen analysis was performed in accordance with WHO criteria and sperm apoptosis and protamine deficiency were evaluated by cell apoptosis detection kit and chromomycin A3, respectively.
resultsResults showed significant different between normal morphology and total motility in two groups. Case group had higher percentage of spermatozoa with protamine deficiency and apoptosis compared to controls significantly.
conclusionOur results showed that in cases of RSA, in addition to abnormal sperm parameters, we have a high percentage of spermatozoa with protamine deficiency and apoptosis and these two anomalies may consider as important causes of idiopathic recurrent abortions. It should be advised that sperm chromatin and DNA examinations are useful tools in the process of RSA treatments.
Indexed as
Identifiers
27294219PMC4899764W2341927956What OpenQuestion holds
Registered trials
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