Cross-Coupling Biarylation of Nitroaryl Chlorides Through High Speed Ball Milling.

Solita Lam, Yvonne Puplampu-Dove, Adrienne Morris, Ayunna Epps, Ghislain Mandouma

Abstract read

In one paragraph

Article in International journal for innovation education and research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Solita LamDepartment of Natural & Forensic Sciences, Albany State University, Albany GA 31705.

Yvonne Puplampu-DoveDepartment of Natural & Forensic Sciences, Albany State University, Albany GA 31705.

Adrienne MorrisDepartment of Natural & Forensic Sciences, Albany State University, Albany GA 31705.

Ayunna EppsDepartment of Natural & Forensic Sciences, Albany State University, Albany GA 31705.

Ghislain MandoumaDepartment of Natural & Forensic Sciences, Albany State University, Albany GA 31705.

Funding

Albany State University Minority Access to Biomedical Careers - ASU MARC to T34GM100881 · NIGMS · ALBANY STATE UNIVERSITY · PI JAIN, ASHOK · 2012 to 2016

$1.0M

NIGMS NIH HHS T34 GM100881

6 · The paper itself

Abstract

Solvent-free reaction using a high-speed ball milling technique has been applied to the classical Ullmann coupling reaction. Cross-coupling biarylation of several nitroaryl chlorides was achieved in good yields when performed in custom-made copper vials through continuous shaking without additional copper or solvent. Cross-coupling products were obtained almost pure and NMR-ready. These reactions were cleaner than solution phase coupling which require longer reaction time in high boiling solvents, and added catalysts as well as lengthy extraction and purification steps. Gram quantities of cross biaryl compounds have been synthesized with larger copper vials, a proof that this method can be used to reduce industrial waste and for sustainability.

Indexed as

Ball MillingBiarylationCross-couplingHigh SpeedSolvent-free ReactionUllmann

Identifiers

PMID27294205

PMCPMC4902293

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.