ArticleeNeuro
GABA Receptors on Orexin and Melanin-Concentrating Hormone Neurons Are Differentially Homeostatically Regulated Following Sleep Deprivation.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- GABALAGEN Alleviates Stress-Induced Sleep Disorders in Rats.Biomedicines · 2024Article
- Baseline prepulse inhibition dependency of orexin A and REM sleep deprivation.Psychopharmacology · 2024Article
- The potential role of the orexin system in premenstrual syndrome.Frontiers in endocrinology · 2023Review
- Overexpression of ORX or MCH Protects Neurological Function Against Ischemic Stroke.Neurotoxicity research · 2022Article
- A circuit perspective on narcolepsy.Sleep · 2020Article
- Bmal1 knockdown suppresses wake and increases immobility without altering orexin A, corticotrophin-releasing hormone, or glutamate decarboxylase.CNS neuroscience & therapeutics · 2018Article
- Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of "Chronoconnectivity".Frontiers in pharmacology · 2018Review
- Homeostatic regulation through GABA and acetylcholine muscarinic receptors of motor trigeminal neurons following sleep deprivation.Brain structure & function · 2017Article
- Descending projections from the basal forebrain to the orexin neurons in mice.The Journal of comparative neurology · 2017Article
- Homeostatic Changes in GABA and Glutamate Receptors on Excitatory Cortical Neurons during Sleep Deprivation and Recovery.Frontiers in systems neuroscience · 2017Article
- The role of the GABAergic system on insomnia.Tzu chi medical journalReview
- Article
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Authors and funding
3 authors.
Funding
Abstract
Though overlapping in distribution through the hypothalamus, orexin (Orx) and melanin-concentrating hormone (MCH) neurons play opposite roles in the regulation of sleep-wake states. Orx neurons discharge during waking, whereas MCH neurons discharge during sleep. In the present study, we examined in mice whether GABAA and GABAB receptors (Rs) are present on Orx and MCH neurons and might undergo differential changes as a function of their different activities following sleep deprivation (SD) and sleep recovery (SR). Applying quantitative stereological image analysis to dual-immunofluorescent stained sections, we determined that the proportion of Orx neurons positively immunostained for GABAARs was significantly higher following SD (∼48%) compared with sleep control (SC; ∼24%) and SR (∼27%), and that the luminance of the GABAARs was significantly greater. In contrast, the average proportion of the MCH neurons immunostained for GABAARs was insignificantly lower following SD (∼43%) compared with SC (∼54%) and SR (56%), and the luminance of the GABAARs was significantly less. Although, GABABRs were observed in all Orx and MCH neurons (100%), the luminance of these receptors was differentially altered following SD. The intensity of GABABRs in the Orx neurons was significantly greater after SD than after SC and SR, whereas that in the MCH neurons was significantly less. The present results indicate that GABA receptors undergo dynamic and differential changes in the wake-active Orx neurons and the sleep-active MCH neurons as a function of and homeostatic adjustment to their preceding activity and sleep-wake state.
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