ArticleJournal of thoracic disease2016
Gross tumor volume is the prognostic factor for squamous cell esophageal cancer patients treated with definitive radiotherapy.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Dose escalation based onRadiation oncology (London, England) · 2022Trial
- Dynamic contrast-enhanced magnetic resonance imaging-derived three-dimensional tumor volume improves prognostic stratification in breast cancer: a retrospective cohort study.Gland surgery · 2026Article
- Association between tumor volume changes during neoadjuvant chemoimmunotherapy and survival outcomes in esophageal squamous cell carcinoma: a multicenter study.Frontiers in immunology · 2026Article
- Real-world outcomes after concurrent chemo-radiotherapy in patients with locally advanced esophageal and gastroesophageal junction cancer.Acta oncologica (Stockholm, Sweden) · 2025Article
- Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- A preoperative prediction of lymph node metastasis in early cervical squamous cell cancer with hematologica - based model.Journal of Cancer · 2023Article
- Article
- Prognostic values of the gross volume of metastatic lymph nodes in patients with esophageal squamous cell carcinoma treated with definitive concurrent chemoradiotherapy.Frontiers in oncology · 2022Article
- Gross Tumor Volume Definition and Comparative Assessment for Esophageal Squamous Cell Carcinoma From 3DFrontiers in oncology · 2022Article
- A Radiomics Nomogram for Non-Invasive Prediction of Progression-Free Survival in Esophageal Squamous Cell Carcinoma.Frontiers in computational neuroscience · 2022Article
- Significance of intratreatment tumor volume change during chemoradiotherapy for potentially resectable thoracic esophageal squamous cell carcinoma.American journal of translational research · 2022Article
- Primary gross tumor volume is prognostic and suggests treatment in upper esophageal cancer.BMC cancer · 2021Article
- Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?Clinical and translational radiation oncology · 2020Article
- Analysis of influencing factors of no/low response to preoperative concurrent chemoradiotherapy in locally advanced rectal cancer.PloS one · 2020Article
- Intratreatment Tumor Volume Change During Definitive Chemoradiotherapy is Predictive for Treatment Outcome of Patients with Esophageal Carcinoma.Cancer management and research · 2020Article
- Prognostic Value of CT Imaging-Based Tumor Volume in Patients With Non-Surgical Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
- The Predictive Value of Tumor Volume and Its Change on Short-Term Outcome for Esophageal Squamous Cell Carcinoma Treated With Radiotherapy or Chemoradiotherapy.Frontiers in oncology · 2020Article
- Stage III Esophageal Squamous Cell Carcinoma Patients With Three-Dimensional Conformal or Intensity-Modulated Radiotherapy: A Multicenter Retrospective Study.Frontiers in oncology · 2020Article
- The Prognostic Significance of Metastatic Nodal Size in Non-surgical Patients With Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
- Volumetric imaging parameters are significant for predicting the pathological complete response of preoperative concurrent chemoradiotherapy in local advanced rectal cancer.Journal of radiation research · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate whether gross tumor volume (GTV) defined on radiotherapy planning scans a prognostic factor for esophageal squamous cell carcinoma (ESCC) patients treated with definitive radiotherapy.
methodsFrom 2008 to 2011, 187 ESCC patients who were treated with definitive radio(chemo)therapy were analyzed retrospectively. Tumor volumes such as GTV, gross tumor volume of primary esophageal cancer (GTV-P), and gross tumor volume of metastases lymph nodes (GTV-N) were computed by Philips Healthcare radiation therapy planning system (Pinnacle 8.0). Kaplan-Meier cumulative probability and Cox proportional hazards regression models were used to assess the effect of the clinical factors along with tumor volume on progression-free survival (PFS) and overall survival (OS).
resultsIn the univariate analysis, fraction dose, TNM stage, total radiation dose, GTV, GTV-P, and GTV-N were all significantly associated with both OS and PFS (P<0.05). While in multivariate analysis, GTV and fraction dose were significantly associated with both OS and PFS (adjusted P<0.05) with adjustment for age, sex, smoking status, chemotherapy, fraction dose, GTV, and radiation dose.
conclusionsGTV may serve as a good prognostic factor for ESCC patients treated with definitive radiotherapy. Larger prospective studies are needed to validate these findings.
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