ArticleConservation physiology2015
Manipulating glucocorticoids in wild animals: basic and applied perspectives.
Article in Conservation physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 96 citations in OpenAlex.
- Manipulating Individual State During Migration: Carry-Over Effects of Cumulative Stress on Survival.Ecology and evolution · 2025Article
- Depletion ofInternational journal of molecular sciences · 2025Article
- Temporal Dynamics of Plasma Catecholamines, Metabolic and Immune Markers, and the Corticosterone:DHEA Ratio in Farmed Crocodiles before and after an Acute Stressor.Animals : an open access journal from MDPI · 2024Article
- Evaluation of the effects of exogenous cortisol manipulation and the glucocorticoid antagonist, RU486, on the exploratory tendency of bluegill sunfish (Lepomis macrochirus).Fish physiology and biochemistry · 2023Article
- Different Types of Glucocorticoids to Evaluate Stress and Welfare in Animals and Humans: General Concepts and Examples of Combined Use.Metabolites · 2023Review
- The cost of sympatry: spatio-temporal patterns in leopard dietary and physiological responses to tiger competition gradient in Rajaji Tiger Reserve, Uttarakhand, India.Conservation physiology · 2023Article
- Towards the integration of ecophysiology with fisheries stock assessment for conservation policy and evaluating the status of the Mediterranean Sea.Conservation physiology · 2022Article
- Viviparous mothers impose stronger glucocorticoid-mediated maternal stress effects on their offspring than oviparous mothers.Ecology and evolution · 2021Article
- Heterothermy as a mechanism to offset energetic costs of environmental and homeostatic perturbations.Scientific reports · 2021Article
- Health Status and Stress in Different Categories of Racing Pigeons.Animals : an open access journal from MDPI · 2021Article
- Small mammal glucocorticoid concentrations vary with forest fragment size, trap type, and mammal taxa in the Interior Atlantic Forest.Scientific reports · 2021Article
- An Investigation of the Effect of Catecholamines and Glucocorticoids on the Growth and Pathogenicity ofPathogens (Basel, Switzerland) · 2020Article
- Differential antipredatory responses in the tuco-tuco (Ctenomys talarum) in relation to endogenous and exogenous changes in glucocorticoids.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- A tale of two islands: evidence for impaired stress response and altered immune functions in an insular pit viper following ecological disturbance.Conservation physiology · 2020Article
- Cortisol modulates metabolism and energy mobilization in wild-caught pumpkinseed (Lepomis gibbosus).Fish physiology and biochemistry · 2019Article
- Exogenous glucocorticoids amplify the costs of infection by reducing resistance and tolerance, but effects are mitigated by co-infection.Proceedings. Biological sciences · 2019Article
- Glucocorticoids and "Stress" Are Not Synonymous.Integrative organismal biology (Oxford, England) · 2019Article
- Chronic Plasma Cortisol Elevation Does Not Promote Riskier Behavior in a Teleost Fish: A Test of the Behavioral Resiliency Hypothesis.Integrative organismal biology (Oxford, England) · 2019Article
- Associations between glucocorticoids and sociality across a continuum of vertebrate social behavior.Ecology and evolution · 2018Review
- The conservation physiology toolbox: status and opportunities.Conservation physiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most comprehensively studied responses to stressors in vertebrates is the endogenous production and regulation of glucocorticoids (GCs). Extensive laboratory research using experimental elevation of GCs in model species is instrumental in learning about stressor-induced physiological and behavioural mechanisms; however, such studies fail to inform our understanding of ecological and evolutionary processes in the wild. We reviewed emerging research that has used GC manipulations in wild vertebrates to assess GC-mediated effects on survival, physiology, behaviour, reproduction and offspring quality. Within and across taxa, exogenous manipulation of GCs increased, decreased or had no effect on traits examined in the reviewed studies. The notable diversity in responses to GC manipulation could be associated with variation in experimental methods, inherent differences among species, morphs, sexes and age classes, and the ecological conditions in which responses were measured. In their current form, results from experimental studies may be applied to animal conservation on a case-by-case basis in contexts such as threshold-based management. We discuss ways to integrate mechanistic explanations for changes in animal abundance in altered environments with functional applications that inform conservation practitioners of which species and traits may be most responsive to environmental change or human disturbance. Experimental GC manipulation holds promise for determining mechanisms underlying fitness impairment and population declines. Future work in this area should examine multiple life-history traits, with consideration of individual variation and, most importantly, validation of GC manipulations within naturally occurring and physiologically relevant ranges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.