SynthesisJournal of the International AIDS Society2016
Hepatitis C in HIV-infected individuals: a systematic review and meta-analysis of estimated prevalence in Africa.
Synthesis in Journal of the International AIDS Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Prevalence and Genotype Distribution of Hepatitis C Virus in Kenya: A Systematic Review and Meta-Analysis.Journal of epidemiology and global health · 2024Pooled it
- Seroprevalence of human immunodeficiency virus in African blood donors: a systematic review and meta-analysis.EBioMedicine · 2024Pooled it
- HIV among people who inject drugs in India: a systematic review.BMC public health · 2022Pooled it
- Pooled it
- Prevalence of Hepatitis C Virus in Tuberculosis Patients: A Systematic Review and Meta-Analysis.Ethiopian journal of health sciences · 2019Pooled it
- Hepatitis C prevalence and quality of health services among HIV-positive mothers in the Democratic Republic of the Congo.Scientific reports · 2022Trial
- A Systematic Review and Narrative Synthesis of Factors Impacting Late Diagnosis of Chronic Hepatitis B and C.Health science reports · 2026Review
- Sero-prevalence and associated factors of transfusion-transmitted infections of HBV, HCV, HIV, and syphilis among voluntary blood donors in Gondar District Blood Bank, Ethiopia: a retrospective study.BMC infectious diseases · 2025Article
- Experience with HCV Detection and Molecular Genetic Characterization among Otherwise Healthy Pregnant Women and Their Partners in the Republic of Guinea.Microorganisms · 2024Article
- High false hepatitis C antibody positivity rate in a regionally-inclusive population of non-renumerated blood donors in Uganda.African health sciences · 2024Article
- Article
- Prevalence and risk factors associated with HIV/hepatitis B and HIV/hepatitis C co-infections among people who inject drugs in Mozambique.BMC public health · 2020Article
- Hepatitis C virus antigens enzyme immunoassay for one-step diagnosis of hepatitis C virus coinfection in human immunodeficiency virus infected individuals.World journal of hepatology · 2019Article
- Extremely low hepatitis C prevalence among HIV co-infected individuals in four countries in sub-Saharan Africa.AIDS (London, England) · 2019Article
- A Window Into the HIV Epidemic from a South African Emergency Department.AIDS research and human retroviruses · 2019Article
- Systematic overview of hepatitis C infection in the Middle East and North Africa.World journal of gastroenterology · 2018Article
- Trends in hepatitis B virus testing practices and management in HIV clinics across sub-Saharan Africa.BMC infectious diseases · 2017Review
- Prevalence of hepatitis B and C infection in persons living with HIV enrolled in care in Rwanda.BMC infectious diseases · 2017Article
- Update in HIV-hepatitis C virus coinfection in the direct acting antiviral era.Current opinion in gastroenterology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionAlthough hepatitis C virus (HCV) screening is recommended for all HIV-infected patients initiating antiretroviral therapy, data on epidemiologic characteristics of HCV infection in resource-limited settings are scarce.
methodsWe searched PubMed and EMBASE for studies assessing the prevalence of HCV infection among HIV-infected individuals in Africa and extracted data on laboratory methods used. Prevalence estimates from individual studies were combined for each country using random-effects meta-analysis. The importance of study design, population and setting as well as type of test (anti-HCV antibody tests and polymerase chain reactions) was examined with meta-regression.
resultsThree randomized controlled trials, 28 cohort studies and 121 cross-sectional analyses with 108,180 HIV-infected individuals from 35 countries were included. The majority of data came from outpatient populations (55%), followed by blood donors (15%) and pregnant women (14%). Based on estimates from 159 study populations, anti-HCV positivity prevalence ranged between 3.3% (95% confidence interval (CI) 1.8-4.7) in Southern Africa and 42.3% (95% CI 4.1-80.5) in North Africa. Study design, type of setting and age distribution did not influence this prevalence significantly. The prevalence of replicating HCV infection, estimated from data of 29 cohorts, was 2.0% (95% CI 1.5-2.6). Ten studies from nine countries reported the HCV genotype of 74 samples, 53% were genotype 1, 24% genotype 2, 14% genotype 4 and 9% genotypes 3, 5 or 6.
conclusionsThe prevalence of anti-HCV antibodies is high in HIV-infected patients in Africa, but replicating HCV infection is rare and varies widely across countries.
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