Trial reportScientific reports2016
Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Determinants of fractal motor activity regulation: insights from a large community-dwelling multi-ethnic population.Research square · 2026Article
- Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.European journal of applied physiology · 2025Review
- The potential of depressive symptoms to identify cognitive impairment in ageing.European journal of ageing · 2025Article
- Effect of Physical Exercise on Executive Functions Using the Emotional Stroop Task in Perimenopausal Women: A Pilot Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- Altered Motor Activity Patterns within 10-Minute Timescale Predict Incident Clinical Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Fractals in Neuropsychology and Cognitive Neuroscience.Advances in neurobiology · 2024Article
- Approaches for assessing circadian rest-activity patterns using actigraphy in cohort and population-based studies.Current sleep medicine reports · 2023Article
- Fractal complexity of daily physical activity and cognitive function in a midlife cohort.Scientific reports · 2023Article
- Stride-to-Stride Fluctuations of Human Gait Are Affected By Chronobiology: An Exploratory Study.Advanced biology · 2023Article
- Remote Spectral Light Sensing in the Home Environment: Further Development of the TWLITE Study Concept.Sensors (Basel, Switzerland) · 2023Observational
- Associations Between Wearable-Specific Indicators of Physical Activity Behaviour and Insulin Sensitivity and Glycated Haemoglobin in the General Population: Results from the ORISCAV-LUX 2 Study.Sports medicine - open · 2022Article
- Association of 24-Hour Activity Pattern Phenotypes With Depression Symptoms and Cognitive Performance in Aging.JAMA psychiatry · 2022Article
- Tunable White Light for Elders (TWLITE): A Protocol Demonstrating Feasibility and Acceptability for Deployment, Remote Data Collection, and Analysis of a Home-Based Lighting Intervention in Older Adults.Sensors (Basel, Switzerland) · 2022Article
- Prediction of Incident Dementia Using Patient Temporal Health Status.Studies in health technology and informatics · 2022Article
- Detection of Dementia Signals from Longitudinal Clinical Visits Using One-Class Classification.Proceedings. IEEE International Conference on Healthcare Informatics · 2022Article
- Advanced analytical methods to assess physical activity behavior using accelerometer time series: A scoping review.Scandinavian journal of medicine & science in sports · 2022Article
- Do Daytime Activity, Mood and Unit Tumult Predict Nighttime Sleep Quality of Long-Term Care Residents?Healthcare (Basel, Switzerland) · 2021Article
- Early Alert of Elderly Cognitive Impairment using Temporal Streaming Clustering.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2021Article
- Sleep, rest-activity rhythms and aging: a complex web in Alzheimer's disease?Neurobiology of aging · 2021Article
- Fractal biomarker of activity in patients with bipolar disorder.Psychological medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Cross-sectional studies show that activity fluctuations in healthy young adults possess robust temporal correlations that become altered with aging, and in dementia and depression. This study was designed to test whether or not within-subject changes of activity correlations (i) track the clinical progression of dementia, (ii) reflect the alterations of depression symptoms in patients with dementia, and (iii) can be manipulated by clinical interventions aimed at stabilizing circadian rhythmicity and improving sleep in dementia, namely timed bright light therapy and melatonin supplementation. We examined 144 patients with dementia (70-96 years old) who were assigned to daily treatment with bright light, bedtime melatonin, both or placebos only in a 3.5-year double-blinded randomized clinical trial. We found that activity correlations at temporal scales <~2 hours significantly decreased over time and that light treatment attenuated the decrease by ~73%. Moreover, the decrease of temporal activity correlations positively correlated with the degrees of cognitive decline and worsening of mood though the associations were relatively weak. These results suggest a mechanistic link between multiscale activity regulation and circadian/sleep function in dementia patients. Whether temporal activity patterns allow unobtrusive, long-term monitoring of dementia progression and mood changes is worth further investigation.
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