ArticleThe Journal of physiology2016
A physiological increase in maternal cortisol alters uteroplacental metabolism in the pregnant ewe.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Increasing the Understanding of Nutrient Transport Capacity of the Ovine Placentome.Animals : an open access journal from MDPI · 2024Article
- Prenatal cortisol exposure impairs adrenal function but not glucose metabolism in adult sheep.The Journal of endocrinology · 2024Article
- Effects of hypoxia on uteroplacental and fetoplacental vascular function during pregnancy.Frontiers in physiology · 2024Review
- Effects of poor maternal diet during gestation are detected in F2 offspring.Translational animal science · 2024Article
- Influence of maternal psychological distress during COVID-19 pandemic on placental morphometry and texture.Scientific reports · 2023Article
- Restricted- and over-feeding during gestation decreases growth of offspring throughout maturity.Translational animal science · 2023Article
- Cortisol Regulates Cerebral Mitochondrial Oxidative Phosphorylation and Morphology of the Brain in a Region-Specific Manner in the Ovine Fetus.Biomolecules · 2022Article
- Metabolic Consequences of Glucocorticoid Exposure before Birth.Nutrients · 2022Review
- Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.American journal of physiology. Endocrinology and metabolism · 2022Article
- Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia.Physiological reports · 2021Article
- Glucocorticoid maturation of mitochondrial respiratory capacity in skeletal muscle before birth.The Journal of endocrinology · 2021Article
- Pre- and post-partum variation in wool cortisol and wool micron in Australian Merino ewe sheep (PeerJ · 2021Article
- Maternal hypercortisolemia alters placental metabolism: a multiomics view.American journal of physiology. Endocrinology and metabolism · 2020Article
- Development and thyroid hormone dependence of skeletal muscle mitochondrial function towards birth.The Journal of physiology · 2020Article
- Glucocorticoid regulation of amino acid transport in primary human trophoblast cells.Journal of molecular endocrinology · 2019Article
- Measuring wool cortisol and progesterone levels in breeding maiden Australian merino sheep (Ovis aries).PloS one · 2019Article
- Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy.PloS one · 2019Article
- Ovine uteroplacental and fetal metabolism during and after fetal cortisol overexposure in late gestation.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile.BBA clinical · 2017Article
- Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
key pointsFetal nutrient supply is dependent, in part, upon the transport capacity and metabolism of the placenta. The stress hormone, cortisol, alters metabolism in the adult and fetus but it is not known whether cortisol in the pregnant mother affects metabolism of the placenta. In this study, when cortisol concentrations were raised in pregnant sheep by infusion, proportionately more of the glucose taken up by the uterus was consumed by the uteroplacental tissues while less was transferred to the fetus, despite an increased placental glucose transport capacity. Concomitantly, the uteroplacental tissues produced lactate at a greater rate. The results show that maternal cortisol concentrations regulate uteroplacental glycolytic metabolism, producing lactate for use in utero. Prolonged increases in placental lactate production induced by cortisol overexposure may contribute to the adverse effects of maternal stress on fetal wellbeing. ABSTRACT: Fetal nutrition is determined by maternal availability, placental transport and uteroplacental metabolism of carbohydrates. Cortisol affects maternal and fetal metabolism, but whether maternal cortisol concentrations within the physiological range regulate uteroplacental carbohydrate metabolism remains unknown. This study determined the effect of maternal cortisol infusion (1.2 mg kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.