Evidence map›Paper›PMID 27292233›Full record

ArticleThe British journal of dermatology2016

Statin use and the risk of herpes zoster: a nested case-control study using primary care data from the U.K. Clinical Research Practice Datalink.

A Matthews, M Turkson, H Forbes, S M Langan, L Smeeth, K Bhaskaran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Statin therapy and herpes virus reactivation-response to Zuin et al. paper.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  8. Herpes zoster infection and statins: which implications in clinical practice?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Review
  9. Article
  10. Article
  11. The alpha-herpesviridae in dermatology : Varicella zoster virus.Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017
    Review
  12. Article
  13. [The alpha-herpesviridae in dermatology : Varicella zoster virus. German version].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A MatthewsDepartment of Noncommunicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K.ORCID http://orcid.org/0000-0002-1290-271X
M TurksonDepartment of Noncommunicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K.
H ForbesDepartment of Noncommunicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K.
S M LanganDepartment of Noncommunicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K.
L SmeethDepartment of Noncommunicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K.
K BhaskaranDepartment of Noncommunicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K.

Funding

Department of Health NIHR/CS/010/014Medical Research Council MR/K006584/1Wellcome Trust
6 · The paper itself

Abstract

backgroundStatins are commonly prescribed worldwide and recent evidence suggests that they may increase the risk of herpes zoster (HZ).

objectivesTo quantify the effect of statin exposure on the risk of HZ in the U.K.

methodsA matched case-control study was conducted using data from U.K. primary care and hospital records. Patients > 18 years with an incident diagnosis of HZ were matched to up to four controls for age, sex and general practice. Patients were included in the statin exposure group if they had ever used a statin, and the daily dosage of the most recent statin prescription and the time since the most recent statin prescription were also recorded. The primary outcome was an incident diagnosis of HZ. Odds ratios (ORs) were estimated from conditional logistic regression and adjusted for potential confounders.

resultsA total of 144 959 incident cases of HZ were matched to 549 336 controls. Adjusted analysis suggested strong evidence for an increase in the risk of HZ related to statin exposure (OR 1·13, 95% confidence interval 1·11-1·15). There was also an increased risk when dosages were increased for patients who were currently or had recently been receiving statin treatment (P

conclusionsThese findings are consistent with the hypothesis that statin therapy leads to an increase in the risk of HZ.

Indexed as

AdolescentAdultAgedAged, 80 and overCase-Control StudiesFemaleHerpes ZosterHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedRisk FactorsUnited KingdomYoung AdultHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID27292233
PMCPMC5215701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.