ArticleScientific reports2016
Presence of atypical porcine pestivirus (APPV) genomes in newborn piglets correlates with congenital tremor.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 136 citations in OpenAlex.
- Characterization of Pestivirus scrofae infection in the tissues of a persistently infected boar.Porcine health management · 2026Article
- Viremia and antibody dynamics following atypical porcine pestivirus infection: a cohort study of pigs with congenital tremor.Porcine health management · 2026Article
- Transmission Dynamics of Gilts Persistently Infected with Atypical Porcine Pestivirus.Viruses · 2026Article
- Presence and shedding dynamics of Atypical Porcine Pestivirus (APPV) in semen of breeding boars: implications for virus transmission in pig production.BMC veterinary research · 2026Article
- Cerebellar hypomyelination, white matter vacuolization, and prolonged presence of atypical porcine pestivirus in pigs with congenital tremor type A-II.Veterinary pathology · 2026Article
- Detection and genetic characterization of atypical porcine pestivirus in wild boars in European Russia.Frontiers in microbiology · 2026Article
- First detection and genetic characterization of atypical Porcine pestivirus in pigs, Thailand.Scientific reports · 2025Article
- Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses.Methods and protocols · 2025Article
- Prevalence estimation of Pestivirus scrofae (atypical porcine pestivirus) among Hungarian pig herds and the effects of different sample types on detection rates.Porcine health management · 2025Article
- First detection of atypical porcine pestivirus in piglets affected by congenital tremor in Poland.Veterinary research communications · 2025Article
- Immunogenicity of subunit vaccine of E2 protein against atypical porcine pestivirus in pigs.Frontiers in cellular and infection microbiology · 2025Article
- Isolation and Phylogenetic Analysis of Atypical Porcine Pestivirus Isolates Identified in Russian Swine Herds.Viruses · 2024Article
- Detection of Double-Stranded RNA Intermediates During SARS-CoV-2 Infections of Syrian Golden Hamsters with Monoclonal Antibodies and Its Implications for Histopathological Evaluation of In Vivo Studies.International journal of molecular sciences · 2024Article
- Enhancing the understanding of coinfection outcomes: Impact of natural atypical porcine pestivirus infection on porcine reproductive and respiratory syndrome in pigs.Virus research · 2024Article
- Article
- Genome characteristics of atypical porcine pestivirus from abortion cases in Shandong Province, China.Virology journal · 2023Article
- Isolation and artificial production of atypical porcine pestivirus, using the swine-kidney-derived cell line SK-L.Archives of virology · 2023Article
- Isolation and Molecular Characterization of Atypical Porcine Pestivirus Emerging in China.Viruses · 2023Article
- Screening for atypical porcine pestivirus in Swedish boar semen used for artificial insemination and a characterisation of the seminal RNA microbiome including the virome.BMC veterinary research · 2023Article
- Dynamics of Infection of Atypical Porcine Pestivirus in Commercial Pigs from Birth to Market: A Longitudinal Study.Viruses · 2023Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pestiviruses are highly variable RNA viruses belonging to the continuously growing family Flaviviridae. A genetically very distinct pestivirus was recently discovered in the USA, designated atypical porcine pestivirus (APPV). Here, a screening of 369 sera from apparently healthy adult pigs demonstrated the existence of APPV in Germany with an estimated individual prevalence of 2.4% and ~10% at farm level. Additionally, APPV genomes were detected in newborn piglets affected by congenital tremor (CT), but genomes were absent in unaffected piglets. High loads of genomes were identified in glandular epithelial cells, follicular centers of lymphoid organs, the inner granular cell layer of the cerebellum, as well as in the trigeminal and spinal ganglia. Retrospective analysis of cerebellum samples from 2007 demonstrated that APPV can be found in piglets with CT of unsolved aetiology. Determination of the first European APPV complete polyprotein coding sequence revealed 88.2% nucleotide identity to the APPV sequence from the USA. APPV sequences derived from different regions in Germany demonstrated to be highly variable. Taken together, the results of this study strongly suggest that the presence of APPV genomes in newborn piglets correlates with CT, while no association with clinical disease could be observed in viremic adult pigs.
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