ArticleScientific reports2016
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dock2 Protects Colitis by Facilitating Akkermansia Colonization via Suppressing IL-22-Reg3 Activity.Inflammation · 2026Article
- DOCK2 Deficiency Causes Defects in Antiviral T-Cell Responses and Impaired Control of Herpes Simplex Virus Infection.The Journal of infectious diseases · 2024Article
- Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine.Journal of clinical immunology · 2023Article
- The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.Frontiers in immunology · 2023Article
- Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.Frontiers in immunology · 2023Article
- Characterization of interactions of dietary cholesterol with the murine and human gut microbiome.Nature microbiology · 2022Article
- Insights from DOCK2 in cell function and pathophysiology.Frontiers in molecular biosciences · 2022Review
- Dock2 affects the host susceptibility to Citrobacter rodentium infection through regulating gut microbiota.Gut pathogens · 2021Article
- The role of Dock2 on macrophage migration and functions during Citrobacter rodentium infection.Clinical and experimental immunology · 2021Article
- A comprehensive guide to studying inflammasome activation and cell death.Nature protocols · 2020Article
- Weighted gene correlation network analysis reveals novel regulatory modules associated with recurrent early pregnancy loss.Bioscience reports · 2020Article
- Spontaneous Loss-of-FunctionCrohn's & colitis 360 · 2019Article
- Human DOCK2 Deficiency: Report of a Novel Mutation and Evidence for Neutrophil Dysfunction.Journal of clinical immunology · 2019Article
- A novel 4-gene prognostic signature for hypermutated colorectal cancer.Cancer management and research · 2019Article
- Microbiome and Colorectal Cancer.Current colorectal cancer reports · 2018Article
- Disruption of the epithelial barrier during intestinal inflammation: Quest for new molecules and mechanisms.Biochimica et biophysica acta. Molecular cell research · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Food poisoning is one of the leading causes of morbidity and mortality in the world. Citrobacter rodentium is an enteric pathogen which attaches itself to enterocytes and induces attachment and effacing (A/E) lesions. The ability of the bacterium to cause infection requires subversion of the host actin cytoskeleton. Rac-dependent actin polymerization is activated by a guanine nucleotide exchange factor known as Dedicator of cytokinesis 2 (DOCK2). However, the role of DOCK2 in infectious disease is largely unexplored. Here, we found that mice lacking DOCK2 were susceptible to C. rodentium infection. These mice harbored increased levels of C. rodentium bacteria, showed more pronounced weight loss and inflammation-associated pathology, and were prone to bacterial dissemination to the systemic organs compared with wild-type mice. We found that mice lacking DOCK2 were more susceptible to C. rodentium attachment to intestinal epithelial cells. Therefore, our results underscored an important role of DOCK2 for gastrointestinal immunity to C. rodentium infection.
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