Evidence map›Paper›PMID 27291641›Full record

ReviewNeuroscience2016

Neurobiology of fibromyalgia and chronic widespread pain.

Kathleen A Sluka, Daniel J Clauw

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 317 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
317citing papers in PubMed, 13 pooled it
34.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04502251 phase2 / phase3completednot on this mapstarted 2018, after this paper: background citation

Association of Low Doses of Naltrexone and Transcranial Direct Current Stimulation in Fibromyalgia: Randomized Clinical Trial, Blind, Controlled With Placebo

TypeinterventionalSponsorCentro Universitario La SalleRan2018 to 2020Enrolled92ConditionsFibromyalgiaArmsLow-Dose Naltrexone, Transcranial Direct Current Stimulation, Placebo, Sham Transcranial Direct Current Stimulation
NCT06138171 completednot on this mapstarted 2023, after this paper: background citation

Psychological Layers of Nociplastic Pain: Cluster Analysis of The Role of Personality Traits, Defence Mechanisms, Central Sensitization, and Childhood Traumatic Experiences in Patients With Chronic Migraine, Fibromyalgia, and Vulvodynia

TypeobservationalSponsorUniversity of Roma La SapienzaRan2023 to 2024Enrolled1,006ConditionsFibromyalgia, Chronic Migraine, Headache, VulvodyniaArmsPsychological self-reported measures assesment (questionnaire)
3 · Its place in the literature

Who cites it

317 citing papers in PubMed, 13 syntheses or guidelines pooled it, 641 citations in OpenAlex.

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  4. Brain modulatory effects of rehabilitation interventions in fibromyalgia: a systematic review of magnetic resonance imaging studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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257 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kathleen A SlukaPhysical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, United States. Electronic address: kathleen-sluka@uiowa.edu.
Daniel J ClauwAnesthesiology, Medicine (Rheumatology) and Psychiatry, University of Michigan, United States.
Michigan United · USUniversity of Iowa · US

Funding

Fibromyalgia Activity Study with TENS "FAST"UM1AR063381 · NIAMS · UNIVERSITY OF IOWA · PI CROFFORD, LESLIE J, SLUKA, KATHLEEN A · 2013 to 2017
$3.4M
Centralized Pain Phenotype as a Predictor of Opioid Non-responsivenessR01DA038261 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRUMMETT, CHAD M, CLAUW, DANIEL J · 2015 to 2020
$2.9M
Central Mechanisms involved in the interactions between muscle pain and exerciseR01AR061371 · NIAMS · UNIVERSITY OF IOWA · PI SLUKA, KATHLEEN A · 2012 to 2016
$2.3M
NIAMS NIH HHS R01 AR061371NIAMS NIH HHS UM1 AR063381NIDA NIH HHS R01 DA038261
6 · The paper itself

Abstract

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.

Indexed as

AnimalsBrainChronic PainFibromyalgiaHumansSpinal Cordcentral sensitizationchronic painfibromyalgiahyperalgesianeurobiologypain

Identifiers

PMID27291641
PMCPMC5083139
OpenAlexW2415752306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.