ArticleNeuroscience letters2016
Propofol anesthesia reduces Lempel-Ziv complexity of spontaneous brain activity in rats.
Article in Neuroscience letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Electrophysiological effects of psilocybin co-administered with midazolam.Translational psychiatry · 2026Article
- "Awe-scillations": EEG spectral and complexity representations of awe.bioRxiv : the preprint server for biology · 2025Article
- Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms.eLife · 2025Article
- Entropy and Complexity Tools Across Scales in Neuroscience: A Review.Entropy (Basel, Switzerland) · 2025Review
- Does Cognitive Load Affect Measures of Consciousness?Brain sciences · 2024Article
- Dorsal and median raphe neuronal firing dynamics characterized by nonlinear measures.PLoS computational biology · 2024Article
- Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness.British journal of anaesthesia · 2024Article
- The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle.Neurochemical research · 2023Article
- Altered brain dynamics index levels of arousal in complete locked-in syndrome.Communications biology · 2023Article
- A systematic approach to brain dynamics: cognitive evolution theory of consciousness.Cognitive neurodynamics · 2023Article
- Sensory modality defines the relation between EEG Lempel-Ziv diversity and meaningfulness of a stimulus.Scientific reports · 2023Article
- Sleep and cognition in aging dogs. A polysomnographic study.Frontiers in veterinary science · 2023Article
- Neural complexity is a common denominator of human consciousness across diverse regimes of cortical dynamics.Communications biology · 2022Article
- From temporal to spatial topography: hierarchy of neural dynamics in higher- and lower-order networks shapes their complexity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys.Neuroinformatics · 2022Article
- Paradoxical markers of conscious levels: Effects of propofol on patients in disorders of consciousness.Frontiers in human neuroscience · 2022Article
- Impact of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling.Neuroscience · 2021Article
- Systematic Review: Anesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part B: Effects of Anesthetic Agents, Doses and Timing.Animals : an open access journal from MDPI · 2021Review
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5 authors.
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Abstract
Consciousness is thought to scale with brain complexity, and it may be diminished in anesthesia. Lempel-Ziv complexity (LZC) of field potentials has been shown to be a promising measure of the level of consciousness in anesthetized human subjects, neurological patients, and across the sleep-wake states in rats. Whether this relationship holds for intrinsic networks obtained by functional brain imaging has not been tested. To fill this gap of knowledge, we estimated LZC from large-scale dynamic analysis of functional magnetic resonance images (fMRI) in conscious sedated and unconscious anesthetized rats. Blood oxygen dependent (BOLD) signals were obtained from 30-min whole-brain resting-state scans while the anesthetic propofol was infused intravenously at constant infusion rates of 20mg/kg/h (conscious sedated) and 40mg/kg/h (unconscious). Dynamic brain networks were defined at voxel level by sliding window analysis of regional homogeneity (ReHo) of the BOLD signal. From scans performed at low to high propofol dose, the LZC was significantly reduced by 110%. The results suggest that the difference in LZC between conscious sedated and anesthetized unconscious subjects is conserved in rats and this effect is detectable in large-scale brain network obtained from fMRI.
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