SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Nephrolithiasis, bone mineral density, osteoporosis, and fractures: a systematic review and comparative meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Prevalence of osteoporosis in patients with nephrolithiasis andFrontiers in endocrinology · 2023Pooled it
- Brazilian Guidelines on evaluation and clinical management of Nephrolithiasis: Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Trial
- Association between oxidative balance score, genetic susceptibility and nephrolithiasis: a cohort study based on the UK Biobank.European journal of nutrition · 2026Article
- Combined occurrence of cardiovascular and bone events in individuals with kidney stone disease.Clinical kidney journal · 2026Article
- Phosphate handling as a determinant of osteoporosis in primary hyperparathyroidism.Endocrine connections · 2026Article
- Association between creatinine clearance and lumbar bone mineral density in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Effect of comorbidities and multimorbidity on bone mineral density in patients with osteoporosis.Archives of osteoporosis · 2025Article
- Exploring the link between nephrolithiasis and osteoporosis: implications for clinical management and treatment advancements.International urology and nephrology · 2025Article
- Hydrochlorothiazide and Bone Mineral Density in Patients with Kidney Stones: Post Hoc Analysis of the NOSTONE Trial.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- The association between the presence of kidney stones and the risk of developing osteoporosis: a NHANES-based cross-sectional study and Mendelian randomization analysis.International urology and nephrology · 2025Observational
- Article
- Bone mineral density assessment in patients with cystinuria.Journal of nephrology · 2025Article
- Bone mineral density and sex hormone binding globulin as potential mediators of the causal effect of urolithiasis on osteoporosis risk: a Mendelian randomization.Frontiers in endocrinology · 2025Article
- CT-Detected Arterial Calcification and Ischemic Cardiovascular Risk Assessment in Patients with Upper Urinary Tract Calculi: A Case-Control Study.Risk management and healthcare policy · 2025Article
- Between a Rock and a Short Place-The Impact of Nephrolithiasis on Skeletal Growth and Development Across the Lifespan.Current osteoporosis reports · 2024Review
- The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease-A State-of-the-Art Review.Nutrients · 2024Review
- Risk factors for the comorbidity of osteoporosis/osteopenia and kidney stones: a cross-sectional study.Archives of osteoporosis · 2023Article
- The Reciprocal Relationship between Osteoporosis and Renal Stones.Journal of clinical medicine · 2022Article
- Nephrolithiasis: A Red Flag for Cardiovascular Risk.Journal of clinical medicine · 2022Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our meta-analysis demonstrates that people with nephrolithiasis have decreased bone mineral density, an increased odds of osteoporosis, and potentially an elevated risk of fractures.
introductionPeople with nephrolithiasis might be at risk of reduced bone mineral density (BMD) and fractures, but the data is equivocal. We conducted a meta-analysis to investigate if patients with nephrolithiasis have worse bone health outcomes (BMD), osteoporosis, and fractures versus healthy controls (HCs).
methodsTwo investigators searched major databases for articles reporting BMD (expressed as g/cm
resultsFrom 1816 initial hits, 28 studies were included. A meta-analysis of case-control studies including 1595 patients with nephrolithiasis (mean age 41.1 years) versus 3402 HCs (mean age 40.2 years) was conducted. Patients with nephrolithiasis showed significant lower T-scores values for the spine (seven studies; SMD = -0.69; 95 % CI = -0.86 to -0.52; I
conclusionsNephrolithiasis is associated with lower BMD, an increased risk of osteoporosis, and possibly, fractures. Future screening/preventative interventions targeting bone health might be indicated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.