Trial reportMayo Clinic proceedings2016
Prognostic Value of Adipokines in Predicting Cardiovascular Outcome: Explaining the Obesity Paradox.
Trial report in Mayo Clinic proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00006305 (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Longitudinal Adipokine and Lipid Profiles in Fabry Disease.Journal of clinical medicine · 2026Article
- The Adipokine Axis in Heart Failure: Linking Obesity, Sarcopenia and Cardiac Dysfunction in HFpEF.International journal of molecular sciences · 2026Review
- Pharmacological Treatment of Obesity in Older Adults.Drugs & aging · 2024Review
- Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study.Frontiers in nutrition · 2023Article
- Twelve-week high-fat diet for improving adverse ventricular remodeling post-myocardial infarction by alleviating local inflammation.Annals of translational medicine · 2022Article
- Malnutrition outweighs the effect of the obesity paradox.Journal of cachexia, sarcopenia and muscle · 2022Observational
- Modelling of longitudinal data to predict cardiovascular disease risk: a methodological review.BMC medical research methodology · 2021Article
- Leptin as a Key between Obesity and Cardiovascular Disease.Journal of obesity & metabolic syndrome · 2020Review
- An Overview of the Role of Adipokines in Cardiometabolic Diseases.Molecules (Basel, Switzerland) · 2020Review
- Black rice with giant embryo ameliorates serum C-reactive protein in adults with metabolic syndrome.Journal of clinical biochemistry and nutrition · 2020Article
- Chemerin enhances the adhesion and migration of human endothelial progenitor cells and increases lipid accumulation in mice with atherosclerosis.Lipids in health and disease · 2020Article
- Obesity and the paradox of mortality and heart failure hospitalization in heart failure with preserved ejection fraction.International journal of obesity (2005) · 2020Article
- Proprotein Convertase Subtilisin/Kexin Type 9, Angiopoietin-Like Protein 8, Sortilin, and Cholesteryl Ester Transfer Protein-Friends of Foes for Psoriatic Patients at the Risk of Developing Cardiometabolic Syndrome?International journal of molecular sciences · 2020Review
- Association of Low Leptin with Poor 3-Month Prognosis in Ischemic Stroke Patients with Type 2 Diabetes.Clinical interventions in aging · 2020Observational
- Impact of serum omentin-1 levels on functional prognosis in nondiabetic patients with ischemic stroke.American journal of translational research · 2019Article
- Leptin, cardiovascular diseases and type 2 diabetes mellitus.Acta pharmacologica Sinica · 2018Review
- High Expression of STAT3 in Subcutaneous Adipose Tissue Associates with Cardiovascular Risk in Women with Rheumatoid Arthritis.International journal of molecular sciences · 2017Article
- Obesity-Associated Hypertension: the Upcoming Phenotype in African-American Women.Current hypertension reports · 2017Review
- Impact of overweight and obesity on acute exacerbations of COPD - subgroup analysis of the Taiwan Obstructive Lung Disease cohort.International journal of chronic obstructive pulmonary disease · 2017Observational
- Metabolic Vascular Syndrome: New Insights into a Multidimensional Network of Risk Factors and Diseases.Visceral medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo evaluate the cardiovascular (CV) prognostic value of adipokines in a large prospective cohort of patients participating in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. PATIENTS AND
methodsThe effects of the adipokine levels at baseline and change from baseline on the composite outcome (CV death, myocardial infarction, and stroke) were analyzed using unadjusted and fully adjusted Cox models in 2330 patients with type 2 diabetes and coronary artery disease who had participated in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial (from January 1, 2001, through December 1, 2008).
resultsIn a fully adjusted model, baseline leptin and change from baseline leptin were protective for CV events, whereas baseline adiponectin, baseline tumor necrosis factor α (TNF-α), change from baseline TNF-α, baseline C-reactive protein (CRP), and change from baseline CRP were harmful. The effect of baseline leptin on CV events depended on the body mass index (BMI), such that the hazard ratios (HRs) varied between 0.6 and 1.4 across the BMI quintiles (interaction P=.03). The same was true for baseline adiponectin (HR varied from 0.7 to 1.7; interaction P=.01), change from baseline monocyte chemoattractant protein-1 (HR varied from 0.8 to 1.8; interaction P=.03), change from baseline TNF-α (HR varied from 0.9 to 1.4; interaction P=.02), and change from baseline IL-6 (HR varied from 0.7 to 1.8; interaction P=.005).
conclusionAdipokines are independent predictors of CV events in patients with type 2 diabetes and coronary artery disease. The association between the specific adipokines and CV outcome varies depending on BMI. This reflects the complex pathophysiology of CV disease in obesity and may help explain the "obesity paradox."
trial registrationclinicaltrials.gov Identifier: NCT00006305.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.