ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2016
Prophylactic Use of Antiepileptic Drugs in Patients with Spontaneous Intracerebral Hemorrhage.
Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pediatric Intracerebral Hemorrhage Management-Consensus Statement of the International Pediatric Stroke Organization-Part 1: Acute Phase and Workup.Journal of the American Heart Association · 2026Guideline
- Prophylactic Antiepileptic Drugs in Nontraumatic Intracerebral Hemorrhage: A Network Meta-Analysis.Neurocritical care · 2026Article
- Acute management of spontaneous intracerebral hemorrhage (ICH) in the emergency department.International journal of emergency medicine · 2026Review
- Article
- Golden hour management in the patient with intraparenchymal cerebral hemorrhage: an Italian intersociety document.Journal of anesthesia, analgesia and critical care · 2025Review
- Functional outcome in patients with traumatic or hemorrhagic brain injuries undergoing decompressive craniectomy versus craniotomy and 6-month rehabilitation.Scientific reports · 2023Observational
- Patterns of prophylactic anticonvulsant use in spontaneous intracerebral and subarachnoid hemorrhage: results of a practitioner survey.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Childhood stroke.Nature reviews. Disease primers · 2022Review
- Impact of seizures and their prophylaxis with antiepileptic drugs on rehabilitation course of patients with traumatic or hemorrhagic brain injury.Frontiers in neurology · 2022Article
- A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage.Annals of clinical and translational neurology · 2021Review
- Risk factors for seizures after intracerebral hemorrhage: Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.Clinical neurology and neurosurgery · 2020Article
- Antiepileptic drugs in critically ill patients.Critical care (London, England) · 2018Review
- The Prevalence and Impact of Status Epilepticus Secondary to Intracerebral Hemorrhage: Results from the US Nationwide Inpatient Sample.Neurocritical care · 2018Article
- Update on the Treatment of Spontaneous Intraparenchymal Hemorrhage: Medical and Interventional Management.Current treatment options in neurology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe effect of prophylactic antiepileptic drugs (AEDs) on mortality and functional outcome in patients with intracerebral hemorrhage (ICH) is uncertain.
methodsWe used data from the Virtual International Stroke Trials Archive (VISTA) to evaluate the effect of prophylactic AEDs on ICH outcome. Univariate and multivariate logistic and Cox regression models were designed to determine the impact of prophylactic AEDs on mortality and disability, defined as a modified Rankin Scale (mRS) greater than 3 at 90 days following ICH.
resultsOf the 802 patients with ICH, 81 (10%) received prophylactic AEDs. Patients who received AED prophylaxis had higher ICH volume (median 23.2 cm(3) [IQR 10.5-38.0] versus 14.3 cm(3) [IQR 7.1-27.0], P= .001) and ICH score (median 1 cm(3) [IQR 0-2] versus 1 cm(3) [IQR 0-1], P = .03). In univariate analyses, AED prophylaxis was associated with higher probability of mRS greater than 3 at 90 days (62% versus 49%, P = .03) and a trend towards increased mortality (27% versus 18%, P = .06). Although seizure did not influence ICH outcome, any AED prophylaxis and phenytoin use in particular were both associated with mRS greater than 3 at 90 days (OR 1.66 [1.04-2.66], P = .03 for any AED; OR 1.97 [1.06-3.67], P = .03 for phenytoin prophylaxis) in univariate analyses. After adjustment for components of the ICH score, none of these associations remained significant.
conclusionPatients with higher ICH scores and larger hemorrhages are more likely to receive prophylactic AEDs. We found no independent effect of prophylactic AED treatment on outcome after ICH.
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