ArticleSchizophrenia bulletin2017
A History of Psychosis in Bipolar Disorder is Associated With Gray Matter Volume Reduction.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gray matter bases of psychotic features in adult bipolar disorder: A systematic review and voxel-based meta-analysis of neuroimaging studies.Human brain mapping · 2018Pooled it
- Altered brain dynamics of facial emotion processing in schizophrenia: a combined EEG/fMRI study.Schizophrenia (Heidelberg, Germany) · 2025Article
- The St. Göran Project: A Multipronged Strategy for Longitudinal Studies for Bipolar Disorders.Neuropsychobiology · 2025Article
- Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration.Schizophrenia bulletin · 2022Article
- Different patterns of white matter microstructural alterations between psychotic and non-psychotic bipolar disorder.PloS one · 2022Article
- Altered spatiotemporal consistency in pediatric bipolar disorder patients with and without psychotic symptoms.BMC psychiatry · 2021Article
- Auditory hallucinations across the psychosis spectrum: Evidence of dysconnectivity involving cerebellar and temporal lobe regions.NeuroImage. Clinical · 2021Article
- Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques.BMC psychiatry · 2020Article
- Improved gray matter surface based spatial statistics in neuroimaging studies.Magnetic resonance imaging · 2019Article
- Exploring the neuroanatomical bases of psychotic features in bipolar disorder.Epidemiology and psychiatric sciences · 2017Review
- Emotional dysregulation and stimulant medication in adult ADHD.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychotic symptoms are prevalent in schizophrenia, bipolar disorder, and other psychiatric and neurological disorders, yet the neurobiological underpinnings of psychosis remain obscure. In the last decade, a large number of magnetic resonance imaging studies have shown differences in local gray matter volume between patients with different psychiatric syndromes and healthy controls. Few studies have focused on the symptoms, which these syndromes are constituted of. Here, we test the association between psychosis and gray matter volume by using a sample of 167 subjects with bipolar disorder, with and without a history of psychosis, and 102 healthy controls. Magnetic resonance images were analyzed on group level using a voxel-wise mass univariate analysis (Voxel-Based Morphometry). We found that patients with a history of psychosis had smaller gray matter volume in left fusiform gyrus, the right rostral dorsolateral prefrontal cortex, and the left inferior frontal gyrus compared with patients without psychosis and with healthy controls. There was no volume difference in these areas between the no-psychosis group and healthy controls. These areas have previously been structurally and functionally coupled to delusions and hallucinations. Our finding adds further evidence to the probability of these regions as key areas in the development of psychotic symptoms.
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