ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Early Aging Effect on the Function of the Human Central Olfactory System.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Olfactory Bulb Volume Reflects Olfactory Dysfunction and Network Organization: Insights From the Population-Based Rhineland Study.International forum of allergy & rhinology · 2026Article
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- Smell the Label: Odors Influence Label Perception and Their Neural Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Altered functional connectivity of primary olfactory cortex-hippocampus-frontal cortex in subjective cognitive decline during odor stimulation.Human brain mapping · 2024Article
- Association between dietary zinc intake and olfactory dysfunction: a study based on the NHANES database.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Odor Identification Across Time in Mutation Carriers and Non-Carriers in Autosomal-Dominant Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging.Journal of clinical medicine · 2023Article
- The neural substrates responsible for food odor processing: an activation likelihood estimation meta-analysis.Frontiers in neuroscience · 2023Article
- Sex differences in olfactory cortex neuronal loss in aging.Frontiers in human neuroscience · 2023Article
- Comparative Effects of Repetitive Odor Identification and Odor Memory Tasks on Olfactory Engagement in Older Populations - A Pilot fMRI Study.Neuropsychiatric disease and treatment · 2021Article
- Objective Assessment of Hyposmia in Alzheimer's Disease From Image and Behavior by Combining Pleasant Odor With Unpleasant Odor.Frontiers in neurology · 2021Article
- Diffusion Tensor Imaging of the Olfactory System in Older Adults With and Without Hyposmia.Frontiers in aging neuroscience · 2021Article
- Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management.Frontiers in aging neuroscience · 2020Review
- Different patterns of age-related central olfactory decline in men and women as quantified by olfactory fMRI.Oncotarget · 2017Article
- Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During normal aging process, the smell function declines significantly, starting from the sixth decade of age. While it has been shown that activity in the central olfactory system of seniors responding to odor stimulation is significantly less than that of young people, no information of the aging effect on the functions of this system during normal adulthood and early aging has been gathered. In this study, we used functional magnetic resonance imaging to investigate the olfaction-related brain activity in the central olfactory structures of 43 healthy adult volunteers aged from 22 to 64 years. The participants' smell identification function was negatively correlated with age (r = -.32, p = .037). Significant negative correlation was observed between age and the olfaction-related activities in the bilateral dorsolateral prefrontal cortex, left insular cortex, and left orbitofrontal cortex (p < .001, corrected with cluster size ≥28 voxels). There was no significant correlation observed between age and the activity in the primary olfactory cortex detected in this age group. These results suggest that age-related functional decline in the human brain is more prominent in the secondary and higher-order central olfactory structures than the primary olfactory cortex in the early aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.