ArticleGenome biology and evolution2016
Multigenomic Delineation of Plasmodium Species of the Laverania Subgenus Infecting Wild-Living Chimpanzees and Gorillas.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 41 citations in OpenAlex.
- Remarkable Evolutionary Rate Variations Among Lineages and Among Genome Compartments in Malaria Parasites of Mammals.Molecular biology and evolution · 2024Article
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- Malaria-driven adaptation of MHC class I in wild bonobo populations.Nature communications · 2023Article
- Role ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Host genetic backgrounds: the key to determining parasite-host adaptation.Frontiers in cellular and infection microbiology · 2023Review
- Plasmodium pitheci malaria in Bornean orang-utans at a rehabilitation centre in West Kalimantan, Indonesia.Malaria journal · 2022Article
- The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs.Communications biology · 2022Article
- PMRT1, amBio · 2022Article
- Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes.Nature communications · 2022Article
- Mid-Liver Stage Arrest ofFrontiers in cellular and infection microbiology · 2022Article
- Atlantic Forest Malaria: A Review of More than 20 Years of Epidemiological Investigation.Microorganisms · 2021Review
- Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology.Journal of physiological anthropology · 2021Review
- Ape Origins of Human Malaria.Annual review of microbiology · 2020Review
- Attraction of mosquitoes to primate odours and implications for zoonotic Plasmodium transmission.Medical and veterinary entomology · 2020Article
- Ancient Introgression between Two Ape Malaria Parasite Species.Genome biology and evolution · 2019Article
- Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of P. falciparum malaria in humans.PLoS biology · 2019Article
- Review
- Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework.Malaria journal · 2019Review
- Investigating zoonotic infection barriers to ape Plasmodium parasites using faecal DNA analysis.International journal for parasitology · 2018Article
- Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria.Nature microbiology · 2018Article
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
Abstract
Plasmodium falciparum, the major cause of malaria morbidity and mortality worldwide, is only distantly related to other human malaria parasites and has thus been placed in a separate subgenus, termed Laverania Parasites morphologically similar to P. falciparum have been identified in African apes, but only one other Laverania species, Plasmodium reichenowi from chimpanzees, has been formally described. Although recent studies have pointed to the existence of additional Laverania species, their precise number and host associations remain uncertain, primarily because of limited sampling and a paucity of parasite sequences other than from mitochondrial DNA. To address this, we used limiting dilution polymerase chain reaction to amplify additional parasite sequences from a large number of chimpanzee and gorilla blood and fecal samples collected at two sanctuaries and 30 field sites across equatorial Africa. Phylogenetic analyses of more than 2,000 new sequences derived from the mitochondrial, nuclear, and apicoplast genomes revealed six divergent and well-supported clades within the Laverania parasite group. Although two of these clades exhibited deep subdivisions in phylogenies estimated from organelle gene sequences, these sublineages were geographically defined and not present in trees from four unlinked nuclear loci. This greatly expanded sequence data set thus confirms six, and not seven or more, ape Laverania species, of which P. reichenowi, Plasmodium gaboni, and Plasmodium billcollinsi only infect chimpanzees, whereas Plasmodium praefalciparum, Plasmodium adleri, and Pladmodium blacklocki only infect gorillas. The new sequence data also confirm the P. praefalciparum origin of human P. falciparum.
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