ArticleGenome biology and evolution2016
Genomic Investigation Reveals Highly Conserved, Mosaic, Recombination Events Associated with Capsular Switching among Invasive Neisseria meningitidis Serogroup W Sequence Type (ST)-11 Strains.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Hyperinvasive and quinolone-resistant meningococci cc4821 achieved immune evasion through capsule switching.BMC microbiology · 2026Article
- Genomic and evolutionary insights into a novelMicrobial genomics · 2026Article
- The molecular characteristic of Neisseria meningtidis serogroup X strain emerging in Jiangsu province, China, 2022.BMC microbiology · 2025Article
- Article
- Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape inMicroorganisms · 2023Review
- Genetic variants linked to the phenotypic outcome of invasive disease and carriage ofMicrobial genomics · 2023Article
- Genomic surveillance of Neisseria meningitidis serogroup W in Portugal from 2003 to 2019.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- The Host-Pathogen Interactions and Epicellular Lifestyle ofFrontiers in cellular and infection microbiology · 2022Review
- Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci.Emerging infectious diseases · 2021Article
- Two Cases of Newly Characterized Neisseria Species, Brazil.Emerging infectious diseases · 2020Article
- Meningococcal Quinolone Resistance Originated from Several CommensalAntimicrobial agents and chemotherapy · 2020Article
- Article
- Genetic exchanges are more frequent in bacteria encoding capsules.PLoS genetics · 2018Article
- Neisseria meningitidis disease-associated clones in Amazonas State, Brazil.Infectious diseases (London, England) · 2018Article
- Molecular characterization of invasive meningococcal isolates in Burkina Faso as the relative importance of serogroups X and W increases, 2008-2012.BMC infectious diseases · 2018Article
- Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Challenges and opportunities for meningococcal vaccination in the developing world.Human vaccines & immunotherapeutics · 2018Review
- Vaccine prevention of meningococcal disease in Africa: Major advances, remaining challenges.Human vaccines & immunotherapeutics · 2018Review
- Evolution of Sequence Type 4821 Clonal Complex Meningococcal Strains in China from Prequinolone to Quinolone Era, 1972-2013.Emerging infectious diseases · 2018Article
- Increase of Neisseria meningitidis W:cc11 invasive disease in Chile has no correlation with carriage in adolescents.PloS one · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Neisseria meningitidis is an important cause of meningococcal disease globally. Sequence type (ST)-11 clonal complex (cc11) is a hypervirulent meningococcal lineage historically associated with serogroup C capsule and is believed to have acquired the W capsule through a C to W capsular switching event. We studied the sequence of capsule gene cluster (cps) and adjoining genomic regions of 524 invasive W cc11 strains isolated globally. We identified recombination breakpoints corresponding to two distinct recombination events within W cc11: A 8.4-kb recombinant region likely acquired from W cc22 including the sialic acid/glycosyl-transferase gene, csw resulted in a C→W change in capsular phenotype and a 13.7-kb recombinant segment likely acquired from Y cc23 lineage includes 4.5 kb of cps genes and 8.2 kb downstream of the cps cluster resulting in allelic changes in capsule translocation genes. A vast majority of W cc11 strains (497/524, 94.8%) retain both recombination events as evidenced by sharing identical or very closely related capsular allelic profiles. These data suggest that the W cc11 capsular switch involved two separate recombination events and that current global W cc11 meningococcal disease is caused by strains bearing this mosaic capsular switch.
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