ArticleGenome biology and evolution2016
A Theoretical Lower Bound for Selection on the Expression Levels of Proteins.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression.PLoS genetics · 2026Article
- RNA cis-regulators are important for Streptococcus pneumoniae in vivo success.PLoS genetics · 2024Article
- Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach.eLife · 2018Article
- Article
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2 authors.
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Abstract
We use simple models of the costs and benefits of microbial gene expression to show that changing a protein's expression away from its optimum by 2-fold should reduce fitness by at least [Formula: see text], where P is the fraction the cell's protein that the gene accounts for. As microbial genes are usually expressed at above 5 parts per million, and effective population sizes are likely to be above 10(6), this implies that 2-fold changes to gene expression levels are under strong selection, as [Formula: see text], where Ne is the effective population size and s is the selection coefficient. Thus, most gene duplications should be selected against. On the other hand, we predict that for most genes, small changes in the expression will be effectively neutral.
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