ArticleDevelopmental cognitive neuroscience2016
Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation.
Article in Developmental cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 17 citations in OpenAlex.
- A graph neural network approach to investigate brain critical states over neurodevelopment.Network neuroscience (Cambridge, Mass.) · 2025Article
- Generalizability of 3D CNN models for age estimation in diverse youth populations using structural MRI.Scientific reports · 2023Article
- Ranking-space: magnitude makes sense through spatially scaffolded ranking.Frontiers in psychology · 2023Article
- Identifying Diurnal Variability of Brain Connectivity Patterns Using Graph Theory.Brain sciences · 2021Article
- Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample.The American journal of psychiatry · 2017Article
- What Is the Evidence for Inter-laminar Integration in a Prefrontal Cortical Minicolumn?Frontiers in neuroanatomy · 2017Article
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Authors and funding
19 authors at 4 institutions in 3 countries.
Funding
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Abstract
Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7-15 years old; total N=652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.
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