Evidence map›Paper›PMID 27288601›Full record

ArticleJournal of critical care2016

Elevated red cell distribution width at initiation of critical care is associated with mortality in surgical intensive care unit patients.

Tiffany M N Otero, Cecilia Canales, D Dante Yeh, Peter C Hou, Donna M Belcher, Sadeq A Quraishi

Abstract read
In one paragraph

Article in Journal of critical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  4. Observational
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  7. Red cell distribution width is a predictor of all-cause mortality in hospitalized dogs.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022
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  9. Observational
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  11. Review
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  15. Preoperative red cell distribution width: Not a useful prognostic indicator for 30-day mortality in patients who undergo major- or ultra-major noncardiac surgery.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2016
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tiffany M N OteroTufts University School of Medicine, 136 Harrison Ave, Boston, MA, 02111; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114. Electronic address: totero@partners.org.
Cecilia CanalesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114; University of California, 252 Irvine Hall, Irvine, CA, 92697. Electronic address: canalesc@uci.edu.
D Dante YehDepartment of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115. Electronic address: dyeh2@mgh.harvard.edu.
Peter C HouHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115; Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115. Electronic address: phou@bwh.harvard.edu.
Donna M BelcherDepartment of Nutrition and Food Services, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114. Electronic address: dmbelcher@partners.org.
Sadeq A QuraishiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115. Electronic address: squraishi@mgh.harvard.edu.
Massachusetts General Hospital · USLemuel Shattuck Hospital · USUniversity of California, Irvine · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Research Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8M
Tufts Clinical and Translational Research InstituteTL1TR001062 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$2.1M
Penn State Clinical and Translational Science InstituteTL1TR000125 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$550k
NCATS NIH HHS L30 TR001257NCATS NIH HHS TL1 TR000125NCATS NIH HHS TL1 TR001062NCATS NIH HHS UL1 TR002014NCRR NIH HHS UL1 RR025758NIGMS NIH HHS L30 GM102903NIGMS NIH HHS T32 GM007592
6 · The paper itself

Abstract

purposeRecent evidence suggests that red cell distribution width (RDW) is associated with mortality in mixed cohorts of critically ill patients. Our goal was to investigate whether elevated RDW at initiation of critical care in the intensive care unit (ICU) is associated with 90-day mortality in surgical patients.

methodsWe performed a retrospective, single-center cohort study. Normal RDW was defined as 11.5%-14.5%. To investigate the association of admission RDW with 90-day mortality, we performed a logistic regression analysis, controlling for age, sex, race, body mass index, Nutrition Risk Screening 2002 score, Acute Physiology and Chronic Health Evaluation II score, hospital length of stay, as well as levels of creatinine, albumin, and mean corpuscular volume.

results500 patients comprised the analytic cohort; 47% patients had elevated RDW and overall 90-day mortality was 28%. Logistic regression analysis demonstrated that patients with elevated RDW had a greater than two-fold increased odds of mortality (OR 2.28: 95%CI 1.20-4.33) compared to patients with normal RDW.

conclusionsElevated RDW at initiation of care is associated with increased odds of 90-day mortality in surgical ICU patients. These data support the need for prospective studies to determine whether RDW can improve risk stratification in surgical ICU patients.

Indexed as

AdolescentAdultAgedAPACHEBostonCohort StudiesCritical CareCritical IllnessErythrocyte IndicesFemaleHospitalizationHospitals, UniversityHumansIntensive Care UnitsMaleMiddle AgedCritical careICUMortalityRDWRed cell distribution width

Identifiers

PMID27288601
PMCPMC4903153
OpenAlexW2299160392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.