ArticleThe Journal of infectious diseases2016
Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- High-throughput targeted amplicon screening tool for characterizing intrahost diversity inMicrobial genomics · 2025Article
- Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance.Nature reviews. Microbiology · 2024Review
- Generation and Characterization of Stable Small Colony Variants of USA300Antibiotics (Basel, Switzerland) · 2024Article
- Human Milk-DerivedMicroorganisms · 2024Article
- Article
- Evaluation of within-host evolution of methicillin-resistant Staphylococcus aureus (MRSA) by comparing cgMLST and SNP analysis approaches.Scientific reports · 2022Article
- Prevalence and WGS-based characteristics of MRSA isolates in hospitals in Shanghai, China.Frontiers in microbiology · 2022Article
- Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) prevalence in humans in close contact with animals and measures to reduce on-farm colonisation.Irish veterinary journal · 2021Review
- Curating and comparing 114 strain-specific genome-scale metabolic models of Staphylococcus aureus.NPJ systems biology and applications · 2021Review
- Common Adaptive Strategies Underlie Within-Host Evolution of Bacterial Pathogens.Molecular biology and evolution · 2021Article
- Comparative genomics of ST5 and ST30 methicillin-resistantMicrobial genomics · 2021Article
- Antibiotic resistance and persistence-Implications for human health and treatment perspectives.EMBO reports · 2020Review
- Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistantThe Lancet. Microbe · 2020Observational
- Genomic analyses ofMicrobial genomics · 2020Article
- Genomic epidemiology of MRSA infection and colonization isolates among military trainees with skin and soft tissue infection.Infection · 2019Article
- Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.Nature reviews. Microbiology · 2019Review
- Retrospective Identification of a Broad IgG Repertoire Differentiating Patients WithFrontiers in immunology · 2019Article
- Long-Term Intrahost Evolution of Methicillin ResistantFrontiers in genetics · 2019Article
- USA300 Staphylococcus aureus persists on multiple body sites following an infection.BMC microbiology · 2018Article
- Genome Plasticity ofInfection and immunity · 2018Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundMethicillin-resistant Staphylococcus aureus (MRSA) USA300 is the leading cause of MRSA infections in the United States and has caused an epidemic of skin and soft-tissue infections. Recurrent infections with USA300 MRSA are common, yet intrahost evolution during persistence on an individual has not been studied. This gap hinders the ability to clinically manage recurrent infections and reconstruct transmission networks.
methodsTo characterize bacterial intrahost evolution, we examined the clinical courses of 4 subjects with 3-6 recurrent USA300 MRSA infections, using patient clinical data, including antibiotic exposure history, and whole-genome sequencing and phylogenetic analysis of all available MRSA isolates (n = 29).
resultsAmong sequential isolates, we found variability in diversity, accumulation of mutations, and mobile genetic elements. Selection for antimicrobial-resistant populations was observed through both an increase in the number of plasmids conferring multidrug resistance and strain replacement by a resistant population. Two of 4 subjects had strain replacement with a genetically distinct USA300 MRSA population. DISCUSSIONS: During a 5-year period in 4 subjects, we identified development of antimicrobial resistance, intrahost evolution, and strain replacement among isolates from patients with recurrent MRSA infections. This calls into question the efficacy of decolonization to prevent recurrent infections and highlights the adaptive potential of USA300 and the need for effective sampling.
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