Evidence map›Paper›PMID 27288376›Full record

Trial reportBMJ open2016

Healthy Ageing Through Internet Counselling in the Elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment.

Edo Richard, Susan Jongstra, Hilkka Soininen, Carol Brayne, Eric P Moll van Charante, Yannick Meiller, Bram van der Groep, Cathrien R L Beishuizen, Francesca Mangialasche, Mariagnese Barbera and 9 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 6 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 6 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Clarifying healthy aging: building a common language for policy innovation within the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 5 countries.

Edo RichardDepartment of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.
Susan JongstraDepartment of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Hilkka SoininenInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Carol BrayneDepartment of Public Health and Primary Care, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK.
Eric P Moll van CharanteDepartment of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Yannick MeillerDepartment of Information and Operations Management, ESCP Europe, Paris, France.
Bram van der GroepVital Health Software, Ede, The Netherlands.
Cathrien R L BeishuizenDepartment of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Francesca MangialascheAging Research Center, Karolinska Institutet/Stockholm University, Stockholm, Sweden.
Mariagnese BarberaInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Tiia NganduChronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Nicola ColeyINSERM, University of Toulouse UMR1027, Toulouse, France Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France.
Juliette GuillemontINSERM, University of Toulouse UMR1027, Toulouse, France.
Stéphanie SavyINSERM, University of Toulouse UMR1027, Toulouse, France.
Marcel G W DijkgraafClinical Research Unit, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Ron J G PetersDepartment of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Willem A van GoolDepartment of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Miia KivipeltoInstitute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland Aging Research Center, Karolinska Institutet/Stockholm University, Stockholm, Sweden Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden.
Sandrine AndrieuINSERM, University of Toulouse UMR1027, Toulouse, France Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France.
Academic Medical Center · NLInserm · FRUniversity of Eastern Finland · FIESCP Business School · FRFinnish Institute for Health and Welfare · FIKarolinska Institutet · SEStockholm University · SEUniversité de Toulouse · FRUniversity of Amsterdam · NLUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCardiovascular disease and dementia share a number of risk factors including hypertension, hypercholesterolaemia, smoking, obesity, diabetes and physical inactivity. The rise of eHealth has led to increasing opportunities for large-scale delivery of prevention programmes encouraging self-management. The aim of this study is to investigate whether a multidomain intervention to optimise self-management of cardiovascular risk factors in older individuals, delivered through an coach-supported interactive internet platform, can improve the cardiovascular risk profile and reduce the risk of cardiovascular disease and cognitive decline. METHODS AND ANALYSIS: HATICE is a multinational, multicentre, prospective, randomised, open-label blinded end point (PROBE) trial with 18 months intervention. Recruitment of 2600 older people (≥65 years) at increased risk of cardiovascular disease will take place in the Netherlands, Finland and France. Participants randomised to the intervention condition will have access to an interactive internet platform, stimulating self-management of vascular risk factors, with remote support by a coach. Participants in the control group will have access to a static internet platform with basic health information.The primary outcome is a composite score based on the average z-score of the difference between baseline and 18 months follow-up values of systolic blood pressure, low-density-lipoprotein and body mass index. Main secondary outcomes include the effect on the individual components of the primary outcome, the effect on lifestyle-related risk factors, incident cardiovascular disease, mortality, cognitive functioning, mood and cost-effectiveness. ETHICS AND DISSEMINATION: The study was approved by the medical ethics committee of the Academic Medical Center in Amsterdam, the Comité de Protection des Personnes Sud Ouest et Outre Mer in France and the Northern Savo Hospital District Research Ethics Committee in Finland.We expect that data from this study will result in a manuscript published in a peer-reviewed clinical open access journal. TRIAL REGISTRATION NUMBER: ISRCTN48151589.

Indexed as

Healthy AgingAgedAged, 80 and overCardiovascular DiseasesCognitive DysfunctionCost-Benefit AnalysisCounselingFemaleFinlandFranceHumansInternetLife StyleMaleNetherlandsProspective StudiesCARDIOLOGYEHEALTHNEUROLOGYPREVENTIVE MEDICINEPUBLIC HEALTH

Identifiers

PMID27288376
PMCPMC4908903
OpenAlexW2418271948

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.