ArticleJournal of medical ethics2017
How to keep high-risk studies ethical: classifying candidate solutions.
Article in Journal of medical ethics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment.Journal of medical ethics · 2018Trial
- The ethical case for placebo control in HIV-cure-related studies with ART interruption.Journal of virus eradication · 2022Article
- Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States.BMC medical ethics · 2022Article
- Ethical considerations for HIV remission clinical research involving participants diagnosed during acute HIV infection.BMC medical ethics · 2021Article
- Ethics of HIV cure research: an unfinished agenda.BMC medical ethics · 2021Review
- AIDS Activism and Coronavirus Vaccine Challenge Trials.AIDS and behavior · 2020Article
- Is There an Ethical Upper Limit on Risks to Study Participants?Public health ethics · 2020Article
- Towards Identifying an Upper Limit of Risk: A Persistent Area of Controversy in Research Ethics.Perspectives in biology and medicine · 2020Article
- HIV Cure Research: Risks Patients Expressed Willingness to Accept.Ethics & human research · 2019Article
- The psychology of "cure" - unique challenges to consent processes in HIV cure research in South Africa.BMC medical ethics · 2019Article
- Ethical issues in HIV remission trials.Current opinion in HIV and AIDS · 2018Review
- What can the lived experience of participating in risky HIV cure-related studies establish?Journal of medical ethics · 2018Article
- Invited Commentary on Dubé et al. (Perceptions of Equipoise, Risk/Benefit Ratios, and "Otherwise Healthy Volunteers" in the Context of Early-Phase HIV Cure Research in the United States-A Qualitative Inquiry): Are HIV-Infected Candidates for Participation in Risky Cure-Related Studies Otherwise Healthy?Journal of empirical research on human research ethics : JERHRE · 2018Article
- Perceptions of Equipoise, Risk-Benefit Ratios, and "Otherwise Healthy Volunteers" in the Context of Early-Phase HIV Cure Research in the United States: A Qualitative Inquiry.Journal of empirical research on human research ethics : JERHRE · 2018Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
This article lays out a wide spectrum of candidate ethical solutions for the challenge on which this JME symposium focuses: the benefit:risk ratio challenge to some early-phase HIV cure and remission studies. These candidate solutions fall into four categories: ones that seek to reduce risks in early-phase HIV cure and remission studies, ones that enhance the benefits for these studies' participants (or show that those were adequate in the first place), ones that focus on participants' free and informed consent to participate and ones according to whom the large benefits to non-participants can defeat considerations about individual participant net risks. In so doing, this article also structures the rest of the symposium.
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Registered trials
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