Evidence map›Paper›PMID 27287651›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2016

Isoniazid therapy for Mycobacterium tuberculosis infection in HIV clinics, Los Angeles, California.

S S Shin, A H Chang, J K C Ghosh, M P Dubé, R Bolan, O O Yang, P R Kerndt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

S S ShinDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA; Tuberculosis Control Program, Los Angeles County Department of Public Health, Los Angeles, USA.
A H ChangTuberculosis Control Program, Los Angeles County Department of Public Health, Los Angeles, USA; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, USA.
J K C GhoshTuberculosis Control Program, Los Angeles County Department of Public Health, Los Angeles, USA.
M P DubéKeck School of Medicine, University of Southern California, Los Angeles, USA.
R BolanLos Angeles LGBT Center, Los Angeles, USA.
O O YangDavid Geffen School of Medicine, University of California, Los Angeles, AIDS Healthcare Foundation, Los Angeles, California, USA.
P R KerndtTuberculosis Control Program, Los Angeles County Department of Public Health, Los Angeles, USA.
Los Angeles LGBT Center · USUniversity of Southern California · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BALDWIN, GAYLE COCITA · 1991 to 2018
$39.9M
Postdoctoral Training in Global AIDS Prevention ResearchT32MH080634 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Pamina Mae Gorbach · 2007 to 2026
$6.4M
The Effect of Mixed-strain Mycobacterium tuberculosis Infections on TB Treatment Outcomes in Botswana: A Retrospective Cohort Study.K01AI118559 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIN, SANGHYUK SAM · 2015 to 2019
$670k
Predictors of tuberculosis by stage of insulin resistanceK23AI091688 · NIAID · STANFORD UNIVERSITY · PI CHANG, ALICIA HSIN-MING · 2011 to 2015
$666k
NCATS NIH HHS UL1 TR000124NIAID NIH HHS K01 AI118559NIAID NIH HHS K23 AI091688NIAID NIH HHS P30 AI028697NIMH NIH HHS P30 MH058107NIMH NIH HHS T32 MH080634
6 · The paper itself

Abstract

settingPublicly funded human immunodeficiency virus (HIV) clinics in Los Angeles County, California, USA.

backgroundHIV-infected persons are a high priority group for targeted testing and treatment for Mycobacterium tuberculosis infection in the United States.

objectiveTo describe rates of isoniazid (INH) initiation and completion among HIV-1 and M. tuberculosis co-infected persons in Los Angeles County.

designWe conducted a cross-sectional study using routinely collected surveillance data from publicly funded HIV clinics. We examined differences in INH treatment initiation and completion between four clinic categories: the three largest clinics (Clinics A, B, and C) and 'Other' clinics (pooled data for the remaining 10 clinics).

resultsDuring 2010-2013, 802 (5.3%) of 15 029 HIV-1-infected persons tested positive for M. tuberculosis infection. INH was initiated in 581 (72.4%) persons, of whom 457 (78.7%) completed treatment. We found significant differences between clinics in terms of treatment initiation (range 59.1-93.4%) and completion (range 58.8-82.3%). Overall, 57% (457/802) of HIV and M. tuberculosis co-infected persons completed the recommended treatment (range across clinics 34.8-76.3%).

conclusionWe identified significant gaps in the treatment for M. tuberculosis infection among HIV-infected persons in Los Angeles County. Interventions are needed to improve initiation and completion of treatment for M. tuberculosis infection in this population.

Indexed as

Ambulatory Care FacilitiesCoinfectionAdultAntitubercular AgentsCross-Sectional StudiesFemaleGuideline AdherenceHIV-1HIV InfectionsHumansIsoniazidLos AngelesMaleMedication AdherenceMiddle AgedPractice Guidelines as TopicAntitubercular AgentsIsoniazid

Identifiers

PMID27287651
PMCPMC4905690
OpenAlexW2416449364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.