Evidence map›Paper›PMID 27287605›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016

Patterns of End-Stage Renal Disease Caused by Diabetes, Hypertension, and Glomerulonephritis in Live Kidney Donors.

S Anjum, A D Muzaale, A B Massie, S Bae, X Luo, M E Grams, K L Lentine, A X Garg, D L Segev

Registry-linked trialAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05041829 (Dietary Sodium Intake and Blood Pressure in Living Kidney Donors), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05041829 nasuspendednot on this mapstarted 2021, after this paper: background citation

Dietary Sodium Intake and Blood Pressure in Living Kidney Donors: A Pilot Single-Center Crossover Single-Blind Randomized Controlled Trial

TypeinterventionalSponsorUniversity of California, IrvineRan2021 to 2028Enrolled24ConditionsHypertension, Living Kidney Donor, Dietary Sodium IntakeArmsDietary sodium
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: A systematic review.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Pooled it
  2. Guideline
  3. Donor medicine: An emerging field in nephrology.World journal of nephrology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Evaluating Risk in Kidney Living Donors.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Longitudinal Trajectories of Estimated Glomerular Filtration Rate in a European Population of Living Kidney Donors.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

S AnjumDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
A D MuzaaleDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-3287-6061
A B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
S BaeDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-0098-8816
X LuoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
M E GramsDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
K L LentineDivision of Nephrology, Saint Louis University School of Medicine, St. Louis, MO.
A X GargDivision of Nephrology, Departments of Medicine, Epidemiology, and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON.
D L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK096008
6 · The paper itself

Abstract

Inferences about late risk of end-stage renal disease (ESRD) in live kidney donors have been extrapolated from studies averaging <10 years of follow-up. Because early (<10 years) and late (≥10 years) postdonation ESRD may differ by causal mechanism, it is possible that extrapolations are misleading. To better understand postdonation ESRD, we studied patterns of common etiologies including diabetes, hypertension and glomerulonephritis (GN; as reported by providers) using donor registry data linked to ESRD registry data. Overall, 125 427 donors were observed for a median of 11.0 years (interquartile range 5.3-15.7 years; maximum 25 years). The cumulative incidence of ESRD increased from 10 events per 10 000 at 10 years after donation to 85 events per 10 000 at 25 years after donation (late vs. early ESRD, adjusted for age, race and sex: incidence rate ratio [IRR]

Indexed as

Living DonorsAdolescentAdultDiabetes MellitusFemaleFollow-Up StudiesGlomerular Filtration RateGlomerulonephritisGraft RejectionGraft SurvivalHumansHypertensionKidney Failure, ChronicKidney Function TestsKidney TransplantationMaleclinical research/practicedonors and donation: donor follow-updonors and donation: livingkidney transplantation/nephrology

Identifiers

PMID27287605
PMCPMC6116527

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.