Evidence map›Paper›PMID 27287454›Full record

ArticlePediatric radiology2016

Utility of sedation for young children undergoing dimercaptosuccinic acid renal scans.

Nader Shaikh, Alejandro Hoberman, Ron Keren, Anastasia Ivanova, Harvey A Ziessman, Gang Cui, Tej K Mattoo, Sonika Bhatnagar, Milan D Nadkarni, Marva Moxey-Mims and 1 more

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In one paragraph

Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Interventions for primary vesicoureteric reflux.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Nader ShaikhUniversity of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Division of General Academic Pediatrics, One Children's Hospital Drive, 4401 Penn Ave., Pittsburgh, PA, 15224, USA. nader.shaikh@chp.edu.
Alejandro HobermanUniversity of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Division of General Academic Pediatrics, One Children's Hospital Drive, 4401 Penn Ave., Pittsburgh, PA, 15224, USA.
Ron KerenDivision of General Pediatrics, Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Anastasia IvanovaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Harvey A ZiessmanDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Gang CuiCollaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tej K MattooDivision of Nephrology and Hypertension, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA.
Sonika BhatnagarUniversity of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Division of General Academic Pediatrics, One Children's Hospital Drive, 4401 Penn Ave., Pittsburgh, PA, 15224, USA.
Milan D NadkarniPediatric Emergency Department, Wake Forest School of Medicine, Brenner Children's Hospital, Winston-Salem, NC, USA.
Marva Moxey-MimsNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
William A PrimackUniversity of North Carolina Kidney Center, Chapel Hill, NC, USA.
University of Pittsburgh · USUniversity of North Carolina at Chapel Hill · USBrenner Children's Hospital · USChildren's Hospital of Michigan · USChildren's Hospital of Philadelphia · USJohns Hopkins University · USKidney Associates · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Randomized Intervention for Vesicoureteral Reflux (RIVUR)U01DK074059 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARPENTER, MYRA A. · 2005 to 2012
$11.3M
NIDDK NIH HHS U01 DK074059
6 · The paper itself

Abstract

backgroundNo studies have examined whether use of sedation during a Tc-99 m dimercaptosuccinic acid (DMSA) renal scan reduces patient discomfort.

objectiveTo compare discomfort level during a DMSA scan to the discomfort level during other frequently performed uroradiologic tests, and to determine whether use of sedation during a DMSA scan modifies the level of discomfort. MATERIALS AND

methodsWe examined the discomfort level in 798 children enrolled in the Randomized Intervention for children with Vesicoureteral Reflux (RIVUR) and Careful Urinary Tract Infection Evaluation (CUTIE) studies by asking parents to rate their child's discomfort level with each procedure on a scale from 0 to 10. We compared discomfort during the DMSA scan and the DMSA image quality between centers in which sedation was used >90% of the time (sedation centers), centers in which sedation was used <10% of the time (non-sedation centers), and centers in which sedation was used on a case-by-case basis (selective centers).

resultsMean discomfort level was highest for voiding cystourethrogram (6.4), followed by DMSA (4.0), followed by ultrasound (2.4; P<0.0001). Mean discomfort level during the DMSA scan was significantly higher at non-sedation centers than at selective centers (P<0.001). No difference was apparent in discomfort level during the DMSA scan between sedation centers and selective centers (P=0.12), or between the sedation centers and non-sedation centers (P=0.80). There were no differences in the proportion with uninterpretable DMSA scans according to sedation use.

conclusionSelective use of sedation in children 12-36 months of age can reduce the discomfort level experienced during a DMSA scan.

Indexed as

Procedural SedationChildChild, PreschoolFemaleHumansInfantMalePain MeasurementParentsRadiopharmaceuticalsTechnetium Tc 99m Dimercaptosuccinic AcidVesico-Ureteral RefluxRadiopharmaceuticalsTechnetium Tc 99m Dimercaptosuccinic AcidAnxiolyticChildrenDimercaptosuccinic acidRenal scintigraphySedationUltrasoundVoiding cystourethrogram

Identifiers

PMID27287454
PMCPMC5039057
OpenAlexW2418176606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.