Evidence map›Paper›PMID 27286992›Full record

ArticleJournal of neurointerventional surgery2017

Comprehensive analysis of intra-arterial treatment for acute ischemic stroke due to cervical artery dissection.

Judd Jensen, Kristin Salottolo, Donald Frei, David Loy, Kathryn McCarthy, Jeffrey Wagner, Michelle Whaley, Richard Bellon, David Bar-Or

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurointerventional surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Article
  6. Review
  7. Article
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  10. Review
  11. Article
  12. Management of Blunt Cerebrovascular Injury.Current neurology and neuroscience reports · 2018
    Review
  13. Article
  14. Intentional subintimal carotid stenting of internal carotid dissection in a patient with acute ischaemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Judd JensenDepartment of Neurology, Swedish Medical Center, Englewood, Colorado, USA.
Kristin SalottoloTrauma Research LLC, Swedish Medical Center, Englewood, Colorado, USA.
Donald FreiDepartment of Neurology, Swedish Medical Center, Englewood, Colorado, USA.
David LoyDepartment of Neurology, Swedish Medical Center, Englewood, Colorado, USA.
Kathryn McCarthyDepartment of Neurology, Swedish Medical Center, Englewood, Colorado, USA.
Jeffrey WagnerDepartment of Neurology, Swedish Medical Center, Englewood, Colorado, USA.
Michelle WhaleyDepartment of Neurology, Swedish Medical Center, Englewood, Colorado, USA.
Richard BellonDepartment of Neurology, Swedish Medical Center, Englewood, Colorado, USA.
David Bar-OrTrauma Research LLC, Swedish Medical Center, Englewood, Colorado, USA.
Swedish Medical Center · USRadiology Associates · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe safety and efficacy of intra-arterial treatment (IAT) in patients with acute ischemic stroke (AIS) due to cervical artery dissection (CeAD) has not been formally studied. The purpose of this study was twofold: first, describe a large series with CeAD treated with IAT; second, analyze outcomes with CeAD receiving IAT versus (a) CeAD not treated with IAT, (b) CeAD receiving intravenous thrombolysis (IVT) alone, and (c) non-CeAD mechanism of AIS receiving IAT.

designDemographics, clinical characteristics, treatment, and outcomes were summarized for all CeAD patients treated with IAT from January 2010 to May 2015. Outcomes included favorable 90 day modified Rankin Scale (mRS) score of 0-2, symptomatic intracerebral hemorrhage (sICH), recanalization (Thrombolysis in Cerebral Infarction 2b-3), procedural complications, and mortality. Outcomes were analyzed with χ

resultsThere were 161 patients with CeAD: 24 were treated with IAT and comprised our target population. Dissections were more common in the internal carotid (n=18) than in the vertebral arteries (n=6). All but one patient had intracranial embolus. IAT techniques included thrombectomy (n=19), IA thrombolysis (n=17), stent (n=14), and angioplasty (n=7). Outcomes included favorable 90 day mRS score of 0-2 in 63%, 4 deaths, 1 sICH, and 3 procedural complications. After adjustment, favorable mRS in our target population was similar to comparison populations: (a) in CeAD, IAT versus no IAT (OR 0.62, p=0.56); (b) In CeAD, IAT versus IVT alone (OR 1.32, p=0.79); and (c) IAT in CeAD versus non-CeAD mechanism of AIS (OR 0.58, p=0.34).

conclusionsIAT is a valid alternative therapeutic option for AIS caused by CeAD due to the low complication rate and excellent outcomes observed in this study.

Indexed as

StentsAdultAgedAged, 80 and overAortic DissectionArteriesBrain IschemiaCerebral HemorrhageFemaleHumansInfusions, Intra-ArterialMaleMiddle AgedRetrospective StudiesStrokeThrombectomyDissectionInterventionThrombectomy

Identifiers

PMID27286992
PMCPMC5520253
OpenAlexW2419388792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.