ArticleInternational journal of colorectal disease2016
Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status.
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantitative risk of positive family history in developing colorectal cancer: A meta-analysis.World journal of gastroenterology · 2019Pooled it
- Lower Relative Contribution of Positive Family History to Colorectal Cancer Risk with Increasing Age: A Systematic Review and Meta-Analysis of 9.28 Million Individuals.The American journal of gastroenterology · 2018Pooled it
- Association between cholecystectomy and colorectal cancer: results from the National Health and Nutrition Examination Survey (NHANES) 2017-2023 and Mendelian randomization analyses.Translational cancer research · 2025Article
- Biliary obstruction in pediatric hereditary spherocytosis: a clinical review of 16 cases.BMC pediatrics · 2025Article
- Effect of smoking on the risk of gastrointestinal cancer after cholecystectomy: A national population-based cohort study.World journal of gastrointestinal surgery · 2024Article
- Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level.Cell communication and signaling : CCS · 2022Article
- Review
- The Risk of Colorectal Cancer After Cholecystectomy or Appendectomy: A Population-based Cohort Study in Korea.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018Article
- The association between cholecystectomy and colorectal neoplasm in inflammatory bowel diseases: A population-based cohort study.PloS one · 2017Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
purposeGallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status.
methodsThis study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors.
resultsOverall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54).
conclusionCholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.
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