ArticleEnvironmental health : a global access science source2016
Assessing urinary flow rate, creatinine, osmolality and other hydration adjustment methods for urinary biomonitoring using NHANES arsenic, iodine, lead and cadmium data.
Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Positive Association of Cardiovascular Disease (CVD) with Chronic Exposure to Drinking Water Arsenic (As) at Concentrations below the WHO Provisional Guideline Value: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
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- Heavy Metal Toxicity in Clinical and Environmental Health: Sources, Mechanisms, Diagnostics, and Evidence-Based Management of Mercury, Lead, Cadmium, and Arsenic.International journal of molecular sciences · 2026Review
- Assessing Measurement Invariance in Allostatic Load between Black and White Adolescents.Journal of racial and ethnic health disparities · 2026Article
- Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study.Environmental research · 2025Article
- INFERRING SYNERGISTIC AND ANTAGONISTIC INTERACTIONS IN MIXTURES OF EXPOSURES.The annals of applied statistics · 2025Article
- Internal Cumulated Dose of Toxic Metal(loid)s in a Population Residing near Naturally Occurring Radioactive Material Waste Stacks and an Industrial Heavily Polluted Area with High Mortality Rates in Spain.Journal of xenobiotics · 2025Article
- Variable power functional dilution adjustment of spot urine.Scientific reports · 2025Article
- Gastrointestinal permeability and kidney injury risk during hyperthermia in young and older adults.Experimental physiology · 2025Article
- Trends in NHANES Biomonitored Exposures in California and the United States following Enactment of California's Proposition 65.Environmental health perspectives · 2024Article
- Association of obesity, diabetes, and hypertension with arsenic in drinking water in the Comarca Lagunera province (north-central Mexico).Scientific reports · 2023Article
- Sex-specific associations between nine metal mixtures in urine and urine flow rate in US adults: NHANES 2009-2018.Frontiers in public health · 2023Article
- Investigation on the Association of Copper and Copper-to-Zinc-Ratio in Hair with Acute Coronary Syndrome Occurrence and Its Risk Factors.Nutrients · 2022Article
- Association of water intake and hydration status with risk of kidney stone formation based on NHANES 2009-2012 cycles.Public health nutrition · 2022Article
- Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants.International journal of environmental research and public health · 2022Article
- Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid.Environment international · 2022Article
- Urinary specific gravity measures in the U.S. population: Implications for the adjustment of non-persistent chemical urinary biomarker data.Environment international · 2021Article
- Environmental and human iodine and selenium status: lessons from Gilgit-Baltistan, North-East Pakistan.Environmental geochemistry and health · 2021Article
- Article
- Evaluation of Saccharin and Resveratrol as Extrinsic Markers of Small-Quantity Lipid-Based Nutrient Supplement Consumption in Healthy Women.Current developments in nutrition · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are numerous methods for adjusting measured concentrations of urinary biomarkers for hydration variation. Few studies use objective criteria to quantify the relative performance of these methods. Our aim was to compare the performance of existing methods for adjusting urinary biomarkers for hydration variation.
methodsCreatinine, osmolality, excretion rate (ER), bodyweight adjusted ER (ERBW) and empirical analyte-specific urinary flow rate (UFR) adjustment methods on spot urinary concentrations of lead (Pb), cadmium (Cd), non-arsenobetaine arsenic (As(IMM)) and iodine (I) from the US National Health and Nutrition Examination Survey (NHANES) (2009-2010 and 2011-2012) were evaluated. The data were divided into a training dataset (n = 1,723) from which empirical adjustment coefficients were derived and a testing dataset (n = 428) on which quantification of the performance of the adjustment methods was done by calculating, primarily, the correlation of the adjusted parameter with UFR, with lower correlations indicating better performance and, secondarily, the correlation of the adjusted parameters with blood analyte concentrations (Pb and Cd), with higher correlations indicating better performance.
resultsOverall performance across analytes was better for Osmolality and UFR based methods. Excretion rate and ERBW consistently performed worse, often no better than unadjusted concentrations.
conclusionsOsmolality adjustment of urinary biomonitoring data provides for more robust adjustment than either creatinine based or ER or ERBW methods, the latter two of which tend to overcompensate for UFR. Modified UFR methods perform significantly better than all but osmolality in removing hydration variation, but depend on the accuracy of UFR calculations. Hydration adjustment performance is analyte-specific and further research is needed to establish a robust and consistent framework.
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