ArticleJournal of translational medicine2016
Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH.
Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- High AMH levels are associated with late miscarriage in women with PCOS undergoing frozen-thawed embryo transfer.BMC pregnancy and childbirth · 2026Article
- Identifying cycle-specific predictive factors for clinical pregnancy after recurrent implantation failure: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
- Development and validation of a nomogram integrating endometrial ultrasound parameters to predict clinical pregnancy in frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2026Article
- Effect of different combinations of serum antimüllerian hormone levels and body mass index on pregnancy outcomes in women with polycystic ovary syndrome.AJOG global reports · 2025Article
- High anti-Müllerian hormone level as a predictor of poor pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization/intracytoplasmic sperm injection: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- An additive opinion to the committee opinion of ASRM and SART on the use of preimplantation genetic testing for aneuploidy (PGT-A).Journal of assisted reproduction and genetics · 2025Article
- The construction of machine learning-based predictive models for high-quality embryo formation in poor ovarian response patients with progestin-primed ovarian stimulation.Reproductive biology and endocrinology : RB&E · 2024Article
- Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data.Reproductive biology and endocrinology : RB&E · 2024Review
- Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF.iScience · 2023Article
- A hybrid artificial intelligence model leverages multi-centric clinical data to improve fetal heart rate pregnancy prediction across time-lapse systems.Human reproduction (Oxford, England) · 2023Article
- Anti-Müllerian hormone treatment enhances oocyte quality, embryonic development and live birth rate†.Biology of reproduction · 2022Article
- Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle.BMC pregnancy and childbirth · 2022Article
- Revisiting selected ethical aspects of current clinical in vitro fertilization (IVF) practice.Journal of assisted reproduction and genetics · 2022Review
- Importance of IGF-I levels in IVF: potential relevance for growth hormone (GH) supplementation.Journal of assisted reproduction and genetics · 2022Article
- Stress, anxiety, and depression in infertile couples are not associated with a first IVF or ICSI treatment outcome.BMC pregnancy and childbirth · 2021Article
- High anti-Müllerian hormone levels might not reflect the likelihood of clinical pregnancy rate in IVF/ICSI treatment.JBRA assisted reproduction · 2021Article
- Rate of rebound in follicle growth after cessation of ovarian stimulation in initial non-responders: a prospective cohort study.Journal of ovarian research · 2021Article
- Multifactor Prediction of Embryo Transfer Outcomes Based on a Machine Learning Algorithm.Frontiers in endocrinology · 2021Article
- Why is use of donor eggs not viewed as treatment failure? A call for improvements in treatments with autologous oocytes.Journal of assisted reproduction and genetics · 2020Article
- The ovarian sensitivity index is predictive of live birth chances after IVF in infertile patients.Human reproduction open · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThough outcome models have been proposed previously, it is unknown whether cutoffs in clinical pregnancy and live birth rates at all ages are able to classify in vitro fertilization (IVF) patients into good-, intermediate- and poor prognosis.
methodsWe here in 3 infertile patient cohorts, involving 1247, 1514 and 632 women, built logistic regression models based on 3 functional ovarian reserve (FOR) parameters, including (1) number of good quality embryos, (2) follicle stimulating hormone (FSH, mIU/mL) and (3) anti-Müllerian hormone (AMH, ng/mL), determining whether clinical pregnancy and live birth rates can discriminate between good, intermediate and poor prognosis patients.
resultsAll models, indeed, allowed at all ages for separation by prognosis, though cut offs changed with age. In the embryo model, increasing embryo production resulted in linear improvement of IVF outcomes despite transfer of similar embryo numbers; in the FSH model outcomes and FSH levels related inversely, while the association of AMH followed a bell-shaped polynomial pattern, demonstrating "best" outcomes at mid-ranges. All 3 models demonstrated increasingly poor outcomes with advancing ages, though "best" AMH even above age 43 was still associated with unexpectedly good pregnancy and delivery outcomes. Excessively high AMH, in contrast, was at all ages associated with spiking miscarriage rates.
conclusionsAt varying peripheral serum concentrations, AMH, thus, demonstrates hithero unknown and contradictory effects on IVF outcomes, deserving at different concentrations investigation as a potential therapeutic agent, with pregnancy-supporting and pregnancy-interrupting properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.