ReviewNeuro-oncology2017
Sleep-wake disturbance in patients with brain tumors.
Review in Neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Sleep and Circadian Rhythms in Primary Brain Tumors Patients: An Observational Study
Use of TTFields in Germany in Routine Clinical Care Study PROgram - Daily Activity, Sleep and Neurocognitive Functioning in Newly Diagnosed Glioblastoma Patients Study
Who cites it
60 citing papers in PubMed, 6 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Prevalence, risk factors, and impacts of sleep disturbances in patients with primary brain tumors: a systematic review.Neurosurgical review · 2025Pooled it
- Sleep disorders associated with cranial radiation-A systematic review.Neuro-oncology · 2025Pooled it
- Efficacy of electroacupuncture in the treatment of insomnia in cancer patients: A meta-analysis.Medicine · 2025Pooled it
- Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.Nature communications · 2023Pooled it
- Symptom management in adult brain tumours: A literature review.Nursing open · 2023Pooled it
- Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma.The Cochrane database of systematic reviews · 2019Pooled it
- Symptom network and latent profile analysis in patients after glioma surgery: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Review
- Daily locomotor activity declines with tumor growth and disease progression in glioblastoma.JCI insight · 2026Article
- A New Adjuvant Treatment for Glioblastoma Using Aprepitant, Vortioxetine, Roflumilast and Olanzapine: The AVRO Regimen.International journal of molecular sciences · 2025Review
- Use of psychotropic medications among glioma patients in Denmark, Norway, Sweden, and Wales.Journal of neuro-oncology · 2025Article
- Social Determinants of Health Predict Sleep-Wake Disturbances Among Patients Living With Primary Brain Tumors: A Cross-Sectional Analysis.Cancer medicine · 2025Article
- Sleep loss-induced oncogenic pathways are mediated via the neuron-specific interleukin-1 receptor accessory protein (AcPb).Brain, behavior, and immunity · 2025Article
- Sleep disturbances in brain tumors: a narrative review.Frontiers in oncology · 2025Review
- Comparison of subjectively and objectively measured sleep-wake patterns among patients with primary brain tumors.Neuro-oncology practice · 2024Article
- Assessing sleep in primary brain tumor patients using smart wearables and patient-reported data: Feasibility and interim analysis of an observational study.Neuro-oncology practice · 2024Article
- Article
- Article
- The Correlation of Sleep Disturbance and Location of Glioma Tumors: A Narrative Review.Journal of clinical medicine · 2023Review
- Non-Pharmacologic Approaches to Sleep Problems for Palliative Care Cancer Patients: A Systematic Review.Florence Nightingale journal of nursing · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Sleep-wake disturbances are defined as perceived or actual alterations in sleep that result in impaired daytime functioning. Unlike other cancers, there is limited information about sleep-wake disturbances in adults with primary brain tumors throughout the illness trajectory. Sleep-wake disturbance is among the most severe and common symptoms reported by primary brain-tumor patients, particularly those undergoing radiation therapy. As with other cancers and neurologic illness, sleep-wake disturbance may also be clustered or related to other symptoms such as fatigue, depression, and cognitive impairment. There is increasing evidence for a genetic basis of normal sleep and sleep regulation in healthy adults. Specific mutations and single nucleotide variants have been reported to be associated with both fatigue and sleep-wake disorders, and both inflammation and alterations in circadian rhythms have been postulated to have a potential role. Guidelines for assessment and interventions have been developed, with cognitive behavioral therapy, exercise, and sleep hygiene demonstrating benefit in patients with other solid tumors. Further research is needed to identify risk and appropriate treatment in the brain-tumor patient population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.