Evidence map›Paper›PMID 27286693›Full record

Trial reportWorld journal of pediatrics : WJP2016

Effect of gluten free diet on gastrointestinal and behavioral indices for children with autism spectrum disorders: a randomized clinical trial.

Faezeh Ghalichi, Jamal Ghaemmaghami, Ayyoub Malek, Alireza Ostadrahimi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of pediatrics : WJP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 8 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 8 syntheses or guidelines pooled it, 151 citations in OpenAlex.

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  8. AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW ABOUT NUTRITIONAL INTERVENTIONS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Faezeh GhalichiNutrition Research Center, Faculty of Nutrition and Food Sciences, Biochemistry and Diet Therapy, Tabriz University of Medical Sciences, Tabriz, Iran.
Jamal GhaemmaghamiFaculty of Nutrition and Food Sciences, Biochemistry and Diet Therapy, Tabriz University of Medical Sciences, Tabriz, Iran.
Ayyoub MalekClinical Psychiatry Research Center, Department of Psychiatry, Tabriz University of Medical Sciences, Tabriz, Iran.
Alireza OstadrahimiDepartment of Biochemistry and Diet Therapy, Tabriz University of Medical Sciences, Tabriz, Iran. Ostadrahimi@tbzmed.ac.ir.
Tabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic and environmental factors are both responsible for the etiology of autism spectrum disorders (ASD). Although epidemiological studies have been conducted to clarify the association between restriction diets and ASD, the conclusion remains unclear. This study was undertaken to investigate the effect of gluten free diet (GFD) on gastrointestinal symptoms and behavioral indices in children with ASD.

methodsIn this randomized clinical trial, 80 children diagnosed with ASD by the Autism Diagnostic Interview-Revised (ADI-R) were assigned into GFD (n=40) and regular diet (RD) (n=40) groups for 6 weeks. At the beginning and end of the intervention, the ROME Ш questionnaire for evaluating gastrointestinal symptoms and Gilliam Autism Rating Scale 2 questionnaire (GARS-2) for assessing psychometric properties were completed.

resultsOf the 80 children, 53.9% had gastrointestinal abnormalities. In the GFD group, the prevalence of gastrointestinal symptoms decreased significantly (P<0.05) after intake of GFD (40.57% vs. 17.10%) but increased insignificantly in the RD group (42.45% vs. 44.05%). GFD intervention resulted in a significant decrease in behavioral disorders (80.03±14.07 vs. 75.82±15.37, P<0.05) but an insignificant increase in the RD group (79.92±15.49 vs. 80.92±16.24).

conclusionThis study suggested that GFD may be effective in controlling gastrointestinal symptoms and ASD behaviors.

Indexed as

Diet, Gluten-FreeAdolescentAnalysis of VarianceAutism Spectrum DisorderChildChild BehaviorChild, PreschoolFemaleFollow-Up StudiesGastrointestinal DiseasesHumansIranMalePatient SelectionReference ValuesSeverity of Illness Indexautismbehavior disorders/problemsgastrointestinal systemgluten free diet

Identifiers

PMID27286693
OpenAlexW2409555233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.