Evidence map›Paper›PMID 27286478›Full record

ReviewAnesthesiology2016

Immune Modulation by Volatile Anesthetics.

Lindsay M Stollings, Li-Jie Jia, Pei Tang, Huanyu Dou, Binfeng Lu, Yan Xu

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03974984 (Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery), which is not on this map. Cited by 144 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03974984 withdrawnnot on this mapstarted 2020, after this paper: background citation

Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery

TypeobservationalSponsorUniversity of CopenhagenRan2020 to 2020Enrolled0ConditionsAnesthesia, Colon Cancer, SurgeryArmsColon Resection, Epidural anesthesia, NSAID
3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Association Between Anesthesia Delivered During Tumor Resection and Cancer Survival: a Systematic Review of a Mixed Picture with Constant Themes.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Pooled it
  4. Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2019
    Pooled it
  5. Pooled it
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  18. Review of the Effects of Anesthetic Techniques and Medications on the Immune Response During the Perioperative Period.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  19. Review
  20. Article

84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lindsay M StollingsDepartments of Anesthesiology (L.M.S., P.T., Y.X.), Immunology (B.L.), Pharmacology and Chemical Biology (P.T., Y.X.), Computational and Systems Biology (P.T.), and Structural Biology (Y.X.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (L.-J.J.); and Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas (H.D.).
Li-Jie Jia
Pei Tang
Huanyu Dou
Binfeng Lu
Yan Xu

Funding

Research Training in Anesthesiology and Pain MedicineT32GM075770 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YAN XU · 2007 to 2026
$4.8M
ANESTHETIC EFFECTS ON ION CHANNEL STRUCTURES & DYNAMICSR01GM066358 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, PEI · 2002 to 2014
$3.6M
Injury Mechanisms and Systemic Immune Responses after Cerebral Global IschemiaR01GM114851 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOU, HUANYU, XU, YAN · 2014 to 2017
$1.8M
NIGMS NIH HHS R01 GM066358NIGMS NIH HHS R01 GM114851NIGMS NIH HHS T32 GM075770
6 · The paper itself

Abstract

Volatile general anesthetics continue to be an important part of clinical anesthesia worldwide. The impact of volatile anesthetics on the immune system has been investigated at both mechanistic and clinical levels, but previous studies have returned conflicting findings due to varied protocols, experimental environments, and subject species. While many of these studies have focused on the immunosuppressive effects of volatile anesthetics, compelling evidence also exists for immunoactivation. Depending on the clinical conditions, immunosuppression and activation due to volatile anesthetics can be either detrimental or beneficial. This review provides a balanced perspective on the anesthetic modulation of innate and adaptive immune responses as well as indirect effectors of immunity. Potential mechanisms of immunomodulation by volatile anesthetics are also discussed. A clearer understanding of these issues will pave the way for clinical guidelines that better account for the impact of volatile anesthetics on the immune system, with the ultimate goal of improving perioperative management.

Indexed as

Adaptive ImmunityAnesthetics, InhalationAnimalsHumansImmunity, InnateImmunologic FactorsAnesthetics, InhalationImmunologic Factors

Identifiers

PMID27286478
PMCPMC5074538

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.