ArticleEnvironmental health perspectives2017
Urinary Concentrations of Parabens and Other Antimicrobial Chemicals and Their Association with Couples' Fecundity.
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality.Frontiers in toxicology · 2024Pooled it
- Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review.Human reproduction update · 2019Pooled it
- Paternal Exposure to Endocrine Disrupting Chemicals and Couples' Pregnancy Outcomes: A Qualitative Review of the Literature.Current environmental health reports · 2026Review
- Biomonitoring of parabens in human milk and placenta and estimated daily intake in northern Taiwan.Journal of exposure science & environmental epidemiology · 2026Article
- Young infants' exposure to parabens: lotion use as a potential source of exposure.Journal of exposure science & environmental epidemiology · 2025Article
- Distribution of Environmental Phenols into Follicular Fluid and Urine of Women Attending Infertility Clinic.Journal of xenobiotics · 2025Article
- Article
- Environmental factors affecting female fertility.Endocrine · 2024Review
- Parabens effects on female reproductive health - Review of evidence from epidemiological and rodent-based studies.Reproductive toxicology (Elmsford, N.Y.) · 2024Review
- Modified Cellulose for Adsorption of Methylparaben and Butylparaben from an Aqueous Solution.ACS omega · 2024Article
- Interference Mechanisms of Endocrine System and Other Systems of Endocrine-Disrupting Chemicals in Cosmetics-In Vitro Studies.International journal of endocrinology · 2024Review
- Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study.Environmental health perspectives · 2023Article
- Urinary phenol concentrations and fecundability and early pregnancy loss.Human reproduction (Oxford, England) · 2023Article
- Polycystic Ovary Syndrome and Endocrine Disruptors (Bisphenols, Parabens, and Triclosan)-A Systematic Review.Life (Basel, Switzerland) · 2023Review
- The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes.Molecular reproduction and development · 2022Review
- Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps.Environment international · 2022Review
- Parabens and Menopause-Related Health Outcomes in Midlife Women: A Pilot Study.Journal of women's health (2002) · 2022Article
- Implications of triclosan for female fertility: results from the National Health and Nutrition Examination Survey, 2013-2016.F&S reports · 2022Article
- Endocrine-Disrupting Chemicals and Breast Cancer: Disparities in Exposure and Importance of Research Inclusivity.Endocrinology · 2022Review
- Environmental factors in declining human fertility.Nature reviews. Endocrinology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHuman exposure to parabens and other antimicrobial chemicals is continual and pervasive. The hormone-disrupting properties of these environmental chemicals may adversely affect human reproduction.
objectiveWe aimed to prospectively assess couples' urinary concentrations of antimicrobial chemicals in the context of fecundity, measured as time to pregnancy (TTP).
methodsIn a prospective cohort of 501 couples, we examined preconception urinary chemical concentrations of parabens, triclosan and triclorcarban in relation to TTP; chemical concentrations were modeled both continuously and in quartiles. Cox's proportional odds models for discrete survival time were used to estimate fecundability odds ratios (FORs) and 95% confidence intervals (CIs) adjusting for
resultsOverall, 347 (69%) couples became pregnant. The highest quartile of female urinary methyl paraben (MP) concentrations relative to the lowest reflected a 34% reduction in fecundity (aFOR = 0.66; 95% CI: 0.45, 0.97) and remained so when accounting for couples' concentrations (aFOR = 0.63; 95% CI: 0.41, 0.96). Similar associations were observed between ethyl paraben (EP) and couple fecundity for both partner and couple-based models (
conclusionsHigher quartiles of preconception urinary concentrations of MP and EP among female partners were associated with reduced couple fecundity in partner-specific and couple-based exposure models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.