ArticleEndocrinology2016
Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core.
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Neuron soma size and density measurements in rat striatal regions disaggregated by sex and estrous cycle phase.Brain structure & function · 2025Article
- Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation.Psychopharmacology · 2024Article
- Review
- Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell.Biology of sex differences · 2023Article
- Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core.Biology of sex differences · 2023Article
- Article
- Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development.Neuropharmacology · 2023Review
- ERα Stimulation Rapidly Modulates Excitatory Synapse Properties in Female Rat Nucleus Accumbens Core.Neuroendocrinology · 2023Article
- The estrous cycle and 17β-estradiol modulate the electrophysiological properties of rat nucleus accumbens core medium spiny neurons.Journal of neuroendocrinology · 2022Review
- Behavioral sex differences in cocaine and opioid use disorders: The role of gonadal hormones.Neuroscience and biobehavioral reviews · 2021Review
- FireMaster® 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster.Hormones and behavior · 2021Article
- Perinatal activation of ERJournal of neurophysiology · 2021Article
- Estrogen receptor alpha, G-protein coupled estrogen receptor 1, and aromatase: Developmental, sex, and region-specific differences across the rat caudate-putamen, nucleus accumbens core and shell.The Journal of comparative neurology · 2021Article
- Acute Ethanol Exposure Enhances Synaptic Plasticity in the Dorsal Striatum in Adult Male and Female Rats.Brain plasticity (Amsterdam, Netherlands) · 2020Article
- Sexual Differentiation and Substance Use: A Mini-Review.Endocrinology · 2020Review
- The estrous cycle modulates rat caudate-putamen medium spiny neuron physiology.The European journal of neuroscience · 2020Article
- Estradiol decreases medium spiny neuron excitability in female rat nucleus accumbens core.Journal of neurophysiology · 2020Article
- Differential and synergistic roles of 17β-estradiol and progesterone in modulating adult female rat nucleus accumbens core medium spiny neuron electrophysiology.Journal of neurophysiology · 2020Article
- Temporal and bidirectional influences of estradiol on voluntary wheel running in adult female and male rats.Hormones and behavior · 2020Article
- Metabotropic glutamate receptor subtype 5 (mGluPhysiology & behavior · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Steroid sex hormones and genetic sex regulate the phenotypes of motivated behaviors and relevant disorders. Most studies seeking to elucidate the underlying neuroendocrine mechanisms have focused on how 17β-estradiol modulates the role of dopamine in striatal brain regions, which express membrane-associated estrogen receptors. Dopamine action is an important component of striatal function, but excitatory synaptic neurotransmission has also emerged as a key striatal substrate and target of estradiol action. Here, we focus on excitatory synaptic input onto medium spiny neurons (MSNs) in the striatal region nucleus accumbens core (AcbC). In adult AcbC, miniature excitatory postsynaptic current (mEPSC) frequency is increased in female compared with male MSNs. We tested whether increased mEPSC frequency in female MSNs exists before puberty, whether this increased excitability is due to the absence of estradiol or testosterone during the early developmental critical period, and whether it is accompanied by stable neuron intrinsic membrane properties. We found that mEPSC frequency is increased in female compared with male MSNs before puberty. Increased mEPSC frequency in female MSNs is abolished after neonatal estradiol or testosterone exposure. MSN intrinsic membrane properties did not differ by sex. These data indicate that neonatal masculinization via estradiol and/or testosterone action is sufficient for down-regulating excitatory synaptic input onto MSNs. We conclude that excitatory synaptic input onto AcbC MSNs is organized long before adulthood via steroid sex hormone action, providing new insight into a mechanism by which sex differences in motivated behavior and other AbcC functions may be generated or compromised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.