SynthesisPloS one2016
Prospective Associations between Depression and Obesity for Adolescent Males and Females- A Systematic Review and Meta-Analysis of Longitudinal Studies.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
190 citing papers in PubMed, 11 syntheses or guidelines pooled it, 413 citations in OpenAlex.
- Shared Determinants of Poor Sleep, Obesity and Adiposity in Adolescents Aged 8-18-Years: A Systematic Review.Journal of sleep research · 2025Pooled it
- Obesity and Psychopathology From Childhood to Adolescence: A Systematic Review of Prospective Studies.Actas espanolas de psiquiatria · 2025Pooled it
- The association between metabolically healthy obesity and risk of depression: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Obesity and its association with mental health among Mexican children and adolescents: systematic review.Nutrition reviews · 2023Pooled it
- Longitudinal association between cardiovascular risk factors and depression in young people: a systematic review and meta-analysis of cohort studies.Psychological medicine · 2023Pooled it
- Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals.Translational psychiatry · 2022Pooled it
- Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies.Translational psychiatry · 2021Pooled it
- Fat compartments in patients with depression: A meta-analysis.Brain and behavior · 2021Pooled it
- Sedentary behaviors and risk of depression: a meta-analysis of prospective studies.Translational psychiatry · 2020Pooled it
- Mobile Apps for the Management of Comorbid Overweight/Obesity and Depression/Anxiety: A Systematic Review.Journal of healthcare engineering · 2020Pooled it
- The Prevalence of Depression and Anxiety Symptoms among Overweight/Obese and Non-Overweight/Non-Obese Children/Adolescents in China: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- Examining cognitive-behavioral therapy change mechanisms for decreasing depression, weight, and insulin resistance in adolescent girls at risk for type 2 diabetes.Journal of psychosomatic research · 2022Trial
- Effects of thyroid hormone and depression on common components of central obesity.The Journal of international medical research · 2019Trial
- Psychometric Validation of the Children's Response Styles Questionnaire in UK Adolescents.Child psychiatry and human development · 2026Article
- Associations of mental health with subsequent weight development during a 4-year follow-up in adolescence.Pediatric research · 2026Article
- Genetic clusters of BMI reveal symptom-specific causal effects on depression.Molecular psychiatry · 2026Article
- A Longitudinal Cohort Study of the Costs of Adolescent Obesity Into Young Adulthood.Obesity science & practice · 2026Article
- The Association Between BMI and Depression Symptoms Among College Students: A Study Based on Random Intercept Cross-Lagged Model.Behavioral sciences (Basel, Switzerland) · 2026Article
- Depression meets obesity: Co-occurrence patterns, temporal trends and socioeconomic correlates across 199 countries and territories.General psychiatry · 2026Article
- Longitudinal and Bidirectional Relationships Between Sleep, Emotional Wellbeing and Weight Status in Childhood and Adolescence: Growing Up in Scotland Cohort Analysis.Journal of sleep research · 2026Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adolescent obesity and depression are increasingly prevalent and are currently recognised as major public health concerns worldwide. The aim of this study is to evaluate the bi-directional associations between obesity and depression in adolescents using longitudinal studies. A systematic literature search was conducted using Pubmed (including Medline), PsycINFO, Embase, CINAHL, BIOSIS Preview and the Cochrane Library databases. According to the inclusion criteria, 13 studies were found where seven studies evaluated depression leading to obesity and six other studies examined obesity leading to depression. Using a bias-adjusted quality effects model for the meta-analysis, we found that adolescents who were depressed had a 70% (RR 1.70, 95% CI: 1.40, 2.07) increased risk of being obese, conversely obese adolescents had an increased risk of 40% (RR 1.40, 95% CI: 1.16, 1.70) of being depressed. The risk difference (RD) of early adolescent depression leading to obesity is 3% higher risk than it is for obesity leading to depression. In sensitivity analysis, the association between depression leading to obesity was greater than that of obesity leading to depression for females in early adulthood compared with females in late adolescence. Overall, the findings of this study suggest a bi-directional association between depression and obesity that was stronger for female adolescents. However, this finding also underscores the importance of early detection and treatment strategies to inhibit the development of reciprocal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.