ArticleRedox biology2016
Plasma cysteine/cystine redox couple disruption in animal models of temporal lobe epilepsy.
Article in Redox biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Hydrogen peroxide sensing and signaling in physiology and disease: implications for therapy.Signal transduction and targeted therapy · 2026Review
- Analytical Methods for Assessing Thiol Antioxidants in Biological Fluids: A Review.Molecules (Basel, Switzerland) · 2024Review
- Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats.Neuroscience bulletin · 2024Article
- The Role of the Vagus Nerve in the Microbiome and Digestive System in Relation to Epilepsy.Current medicinal chemistry · 2024Review
- Article
- Cysteine and homocysteine as biomarker of various diseases.Food science & nutrition · 2020Review
- Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome.Antioxidants & redox signaling · 2020Review
- Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.Brain : a journal of neurology · 2019Article
- Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model.Redox biology · 2019Article
- Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Age-dependent oxidation of extracellular cysteine/cystine redox state (EFree radical biology & medicine · 2018Article
- Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study.Journal of neuroinflammation · 2018Observational
- Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.Brain : a journal of neurology · 2017Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Currently the field of epilepsy lacks peripheral blood-based biomarkers that could predict the onset or progression of chronic seizures following an epileptogenic injury. Thiol/disulfide ratios have been shown to provide a sensitive means of assessing the systemic redox potential in tissue and plasma. In this study, we utilized a rapid, simple and reliable method for simultaneous determination of several thiol-containing amino acids in plasma using HPLC with electrochemical detection in kainic acid (KA) and pilocarpine rat models of epilepsy. In contrast to GSH and GSSG levels, the levels of cysteine (Cys) were decreased by 42% and 62% and cystine (Cyss) were increased by 46% and 23% in the plasma of KA- and pilocarpine-injected rats, respectively after 48h. In chronically epileptic rats, plasma cysteine was decreased by 40.4% and 37.7%, and plasma GSSG increased by 33.8% and 35.0% following KA and pilocarpine, respectively. Treatment of rats with a catalytic antioxidant, 60min after KA or pilocarpine significant attenuated the decrease of plasma Cys/Cyss ratios at the 48h time point in both models. These observations suggest that the decreased cysteine and ratio of Cys/Cyss in plasma could potentially serve as redox biomarkers in temporal lobe epilepsy.
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Registered trials
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