ArticleJournal of dentistry (Shiraz, Iran)2016
A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique.
Article in Journal of dentistry (Shiraz, Iran), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas.Journal of dentistry (Shiraz, Iran) · 2019Article
- IL-4 induces the formation of multinucleated giant cells and expression of β5 integrin in central giant cell lesion.Medicina oral, patologia oral y cirugia bucal · 2017Article
- A comparative study of osteopontin and MMP-2 protein expression in peripheral and central giant cell granuloma of the jaw.Brazilian journal of otorhinolaryngologyArticle
- Unravelling the role of immunohistochemistry in giant cell lesions of jaws: A systematic review.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
statement of the problemPeripheral and central giant cell granuloma are two common benign lesions of the oral cavity. In spite of histopathological similarities, they have different clinical behaviors. Cathepsin D is a lysosomal enzyme which has different functions on the basis of protein and applied peptide cleavage. PURPOSE: This research aimed to evaluate and compare the expression level of Cathepsin D in these two lesions to find the reasons for the differences in clinical and biologic characteristics. MATERIALS AND
methodThe expression of Cathepsin D was investigated by using the immunohistochemistry method in 20 samples of peripheral giant cell granuloma and 20 samples of central giant cell granuloma. The percentage of stained giant cells (labeling index), the intensity of staining of giant cells, and staining-intensity-distribution in both groups were calculated and compared.
resultsThe labeling indices of Cathepsin D in peripheral giant cell granuloma and central giant cell granuloma were 95.9±4.03 and 95.6±2.34, respectively. There was no significant difference in the percentages of stained giant cells between the two groups (p= 0.586). The intensity of staining of giant cells in central giant cell granuloma was stronger than that of peripheral giant cell granuloma (p> 0.001). Staining- intensity- distribution of giant cells in central giant cell granuloma was significantly greater than that of the peripheral type of lesion (p= 0.001).
conclusionThe higher expression level of Cathepsin D in central giant cell granuloma compared to peripheral type of lesion can explain more aggressive behavior of central giant cell granuloma.
Indexed as
Identifiers
27284554PMC4885679W2412096937What OpenQuestion holds
Registered trials
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